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BDBM376031 5'-methyl-N-(1- methylazetidin-3-yl)-5-({[3- (1-methyl-1H-pyrazol-3-yl)-4- (trifluoromethyl)phenyl] carbonyl}amino)-2'H-1,3'- bipyrazole-3-carboxamide::US9914736, Compound 27

SMILES: CN1CC(C1)NC(=O)c1cc(NC(=O)c2ccc(c(c2)-c2ccn(C)n2)C(F)(F)F)n(n1)-c1cc(C)n[nH]1

InChI Key: InChIKey=CXVKCFXNELSRIH-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 376031   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM376031
PNG
(5'-methyl-N-(1- methylazetidin-3-yl)-5-({[3- (1-me...)
Show SMILES CN1CC(C1)NC(=O)c1cc(NC(=O)c2ccc(c(c2)-c2ccn(C)n2)C(F)(F)F)n(n1)-c1cc(C)n[nH]1
Show InChI InChI=1S/C24H24F3N9O2/c1-13-8-21(31-30-13)36-20(10-19(33-36)23(38)28-15-11-34(2)12-15)29-22(37)14-4-5-17(24(25,26)27)16(9-14)18-6-7-35(3)32-18/h4-10,15H,11-12H2,1-3H3,(H,28,38)(H,29,37)(H,30,31)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
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PC cid
PC sid
UniChem
US Patent
n/an/a 10n/an/an/an/an/an/a



University of Namur



Assay Description
 In this assay, U2OS cells express the human TrkA receptor as a fusion with the weakly complementing fragment of B-galactosidase, which DiscoverX cal...

J Med Chem 51: 3077-80 (2008)


BindingDB Entry DOI: 10.7270/Q2WQ0629
More data for this
Ligand-Target Pair