BDBM376069 2-fluoro-N-(1-methyl-3- phenyl-1H-pyrazol-4-yl)-5-(1- methyl-1H-pyrazol-3-yl)-4- (trifluoromethyl)benzamide::US9914736, Compound 65

SMILES: Cn1ccc(n1)-c1cc(C(=O)Nc2cn(C)nc2-c2ccccc2)c(F)cc1C(F)(F)F

InChI Key: InChIKey=WLRKTFXVPQZEDP-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 376069   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM376069 (2-fluoro-N-(1-methyl-3- phenyl-1H-pyrazol-4-yl)-5-...) Show SMILES Cn1ccc(n1)-c1cc(C(=O)Nc2cn(C)nc2-c2ccccc2)c(F)cc1C(F)(F)F Show InChI InChI=1S/C22H17F4N5O/c1-30-9-8-18(28-30)14-10-15(17(23)11-16(14)22(24,25)26)21(32)27-19-12-31(2)29-20(19)13-6-4-3-5-7-13/h3-12H,1-2H3,(H,27,32)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.5	n/a	n/a	n/a	n/a	n/a	n/a
University of Namur					Assay Description In this assay, U2OS cells express the human TrkA receptor as a fusion with the weakly complementing fragment of B-galactosidase, which DiscoverX cal...				J Med Chem 51: 3077-80 (2008) BindingDB Entry DOI: 10.7270/Q2WQ0629
					More data for this Ligand-Target Pair