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BDBM376095 N-(3-((2-aminopyrimidin-5- yl)methyl)-1-(4-fluorophenyl)- 1H-pyrazol-5-yl)-3-(1-methyl- 1H-pyrazol-3-yl)-4- (trifluoromethyl)benzamide::US9914736, Compound 91

SMILES: Cn1ccc(n1)-c1cc(ccc1C(F)(F)F)C(=O)Nc1cc(Cc2cnc(N)nc2)nn1-c1ccc(F)cc1

InChI Key: InChIKey=SOCNRTLMHXSXFI-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 376095   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM376095
PNG
(N-(3-((2-aminopyrimidin-5- yl)methyl)-1-(4-fluorop...)
Show SMILES Cn1ccc(n1)-c1cc(ccc1C(F)(F)F)C(=O)Nc1cc(Cc2cnc(N)nc2)nn1-c1ccc(F)cc1
Show InChI InChI=1S/C26H20F4N8O/c1-37-9-8-22(36-37)20-11-16(2-7-21(20)26(28,29)30)24(39)34-23-12-18(10-15-13-32-25(31)33-14-15)35-38(23)19-5-3-17(27)4-6-19/h2-9,11-14H,10H2,1H3,(H,34,39)(H2,31,32,33)
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MMDB

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PC cid
PC sid
UniChem
US Patent
n/an/a 6.10n/an/an/an/an/an/a



University of Namur



Assay Description
 In this assay, U2OS cells express the human TrkA receptor as a fusion with the weakly complementing fragment of B-galactosidase, which DiscoverX cal...

J Med Chem 51: 3077-80 (2008)


BindingDB Entry DOI: 10.7270/Q2WQ0629
More data for this
Ligand-Target Pair