BindingDB logo
myBDB logout

BDBM376116 N-(3-((2,5-dioxoimidazolidin- 1-yl)methyl)-1-(4- fluorophenyl)-1H-pyrazol-5- yl)-2-fluoro-5-(1-methyl-1H- pyrazol-3-yl)-4- (trifluoromethyl)benzamide::US9914736, Compound 112

SMILES: Cn1ccc(n1)-c1cc(C(=O)Nc2cc(CN3C(=O)CNC3=O)nn2-c2ccc(F)cc2)c(F)cc1C(F)(F)F

InChI Key: InChIKey=AGDLASQMWHJNQZ-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 376116   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM376116
PNG
(N-(3-((2,5-dioxoimidazolidin- 1-yl)methyl)-1-(4- f...)
Show SMILES Cn1ccc(n1)-c1cc(C(=O)Nc2cc(CN3C(=O)CNC3=O)nn2-c2ccc(F)cc2)c(F)cc1C(F)(F)F
Show InChI InChI=1S/C25H18F5N7O3/c1-35-7-6-20(34-35)16-9-17(19(27)10-18(16)25(28,29)30)23(39)32-21-8-14(12-36-22(38)11-31-24(36)40)33-37(21)15-4-2-13(26)3-5-15/h2-10H,11-12H2,1H3,(H,31,40)(H,32,39)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.90n/an/an/an/an/an/a



University of Namur



Assay Description
 In this assay, U2OS cells express the human TrkA receptor as a fusion with the weakly complementing fragment of B-galactosidase, which DiscoverX cal...

J Med Chem 51: 3077-80 (2008)


BindingDB Entry DOI: 10.7270/Q2WQ0629
More data for this
Ligand-Target Pair