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SMILES: C[C@@H]1C[C@H](N)C[C@@H](C1)c1ccncc1NC(=O)c1ccc(F)c2cc(cnc12)-c1c(F)cccc1F

InChI Key: InChIKey=QQISDHWHAQANIC-JZXOWHBKSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 376683   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM376683 (Tert-Butyl {(1S,3R,5S)-3-[3-({[3-(2,6-difluorophen...) Show SMILES C[C@@H]1C[C@H](N)C[C@@H](C1)c1ccncc1NC(=O)c1ccc(F)c2cc(cnc12)-c1c(F)cccc1F |r| Show InChI InChI=1S/C28H25F3N4O/c1-15-9-16(11-18(32)10-15)19-7-8-33-14-25(19)35-28(36)20-5-6-22(29)21-12-17(13-34-27(20)21)26-23(30)3-2-4-24(26)31/h2-8,12-16,18H,9-11,32H2,1H3,(H,35,36)/t15-,16+,18-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
Montana State University					Assay Description Pim-1 and Pim-3 kinase assays—20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...				J Med Chem 50: 4928-38 (2007) BindingDB Entry DOI: 10.7270/Q20G3NF8
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-2 (Homo sapiens (Human))	BDBM376683 (Tert-Butyl {(1S,3R,5S)-3-[3-({[3-(2,6-difluorophen...) Show SMILES C[C@@H]1C[C@H](N)C[C@@H](C1)c1ccncc1NC(=O)c1ccc(F)c2cc(cnc12)-c1c(F)cccc1F |r| Show InChI InChI=1S/C28H25F3N4O/c1-15-9-16(11-18(32)10-15)19-7-8-33-14-25(19)35-28(36)20-5-6-22(29)21-12-17(13-34-27(20)21)26-23(30)3-2-4-24(26)31/h2-8,12-16,18H,9-11,32H2,1H3,(H,35,36)/t15-,16+,18-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Montana State University					Assay Description Pim-2 kinase assay—20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay buffer (50 m...				J Med Chem 50: 4928-38 (2007) BindingDB Entry DOI: 10.7270/Q20G3NF8
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-3 (Homo sapiens (Human))	BDBM376683 (Tert-Butyl {(1S,3R,5S)-3-[3-({[3-(2,6-difluorophen...) Show SMILES C[C@@H]1C[C@H](N)C[C@@H](C1)c1ccncc1NC(=O)c1ccc(F)c2cc(cnc12)-c1c(F)cccc1F |r| Show InChI InChI=1S/C28H25F3N4O/c1-15-9-16(11-18(32)10-15)19-7-8-33-14-25(19)35-28(36)20-5-6-22(29)21-12-17(13-34-27(20)21)26-23(30)3-2-4-24(26)31/h2-8,12-16,18H,9-11,32H2,1H3,(H,35,36)/t15-,16+,18-/m0/s1	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
Montana State University					Assay Description Pim-1 and Pim-3 kinase assays—20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...				J Med Chem 50: 4928-38 (2007) BindingDB Entry DOI: 10.7270/Q20G3NF8
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM376683 (Tert-Butyl {(1S,3R,5S)-3-[3-({[3-(2,6-difluorophen...) Show SMILES C[C@@H]1C[C@H](N)C[C@@H](C1)c1ccncc1NC(=O)c1ccc(F)c2cc(cnc12)-c1c(F)cccc1F |r| Show InChI InChI=1S/C28H25F3N4O/c1-15-9-16(11-18(32)10-15)19-7-8-33-14-25(19)35-28(36)20-5-6-22(29)21-12-17(13-34-27(20)21)26-23(30)3-2-4-24(26)31/h2-8,12-16,18H,9-11,32H2,1H3,(H,35,36)/t15-,16+,18-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories					Assay Description Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...				J Med Chem 50: 641-62 (2007) BindingDB Entry DOI: 10.7270/Q2MP55J7
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-3 (Homo sapiens (Human))	BDBM376683 (Tert-Butyl {(1S,3R,5S)-3-[3-({[3-(2,6-difluorophen...) Show SMILES C[C@@H]1C[C@H](N)C[C@@H](C1)c1ccncc1NC(=O)c1ccc(F)c2cc(cnc12)-c1c(F)cccc1F |r| Show InChI InChI=1S/C28H25F3N4O/c1-15-9-16(11-18(32)10-15)19-7-8-33-14-25(19)35-28(36)20-5-6-22(29)21-12-17(13-34-27(20)21)26-23(30)3-2-4-24(26)31/h2-8,12-16,18H,9-11,32H2,1H3,(H,35,36)/t15-,16+,18-/m0/s1	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-3 (Homo sapiens (Human))	BDBM376683 (Tert-Butyl {(1S,3R,5S)-3-[3-({[3-(2,6-difluorophen...) Show SMILES C[C@@H]1C[C@H](N)C[C@@H](C1)c1ccncc1NC(=O)c1ccc(F)c2cc(cnc12)-c1c(F)cccc1F |r| Show InChI InChI=1S/C28H25F3N4O/c1-15-9-16(11-18(32)10-15)19-7-8-33-14-25(19)35-28(36)20-5-6-22(29)21-12-17(13-34-27(20)21)26-23(30)3-2-4-24(26)31/h2-8,12-16,18H,9-11,32H2,1H3,(H,35,36)/t15-,16+,18-/m0/s1	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories					Assay Description Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...				J Med Chem 50: 641-62 (2007) BindingDB Entry DOI: 10.7270/Q2MP55J7
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM376683 (Tert-Butyl {(1S,3R,5S)-3-[3-({[3-(2,6-difluorophen...) Show SMILES C[C@@H]1C[C@H](N)C[C@@H](C1)c1ccncc1NC(=O)c1ccc(F)c2cc(cnc12)-c1c(F)cccc1F |r| Show InChI InChI=1S/C28H25F3N4O/c1-15-9-16(11-18(32)10-15)19-7-8-33-14-25(19)35-28(36)20-5-6-22(29)21-12-17(13-34-27(20)21)26-23(30)3-2-4-24(26)31/h2-8,12-16,18H,9-11,32H2,1H3,(H,35,36)/t15-,16+,18-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-2 (Homo sapiens (Human))	BDBM376683 (Tert-Butyl {(1S,3R,5S)-3-[3-({[3-(2,6-difluorophen...) Show SMILES C[C@@H]1C[C@H](N)C[C@@H](C1)c1ccncc1NC(=O)c1ccc(F)c2cc(cnc12)-c1c(F)cccc1F |r| Show InChI InChI=1S/C28H25F3N4O/c1-15-9-16(11-18(32)10-15)19-7-8-33-14-25(19)35-28(36)20-5-6-22(29)21-12-17(13-34-27(20)21)26-23(30)3-2-4-24(26)31/h2-8,12-16,18H,9-11,32H2,1H3,(H,35,36)/t15-,16+,18-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-2 (Homo sapiens (Human))	BDBM376683 (Tert-Butyl {(1S,3R,5S)-3-[3-({[3-(2,6-difluorophen...) Show SMILES C[C@@H]1C[C@H](N)C[C@@H](C1)c1ccncc1NC(=O)c1ccc(F)c2cc(cnc12)-c1c(F)cccc1F |r| Show InChI InChI=1S/C28H25F3N4O/c1-15-9-16(11-18(32)10-15)19-7-8-33-14-25(19)35-28(36)20-5-6-22(29)21-12-17(13-34-27(20)21)26-23(30)3-2-4-24(26)31/h2-8,12-16,18H,9-11,32H2,1H3,(H,35,36)/t15-,16+,18-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories					Assay Description Pim-2 kinase assay-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay buffer (50 m...				J Med Chem 50: 641-62 (2007) BindingDB Entry DOI: 10.7270/Q2MP55J7
					More data for this Ligand-Target Pair