null

SMILES: CC(C)N1CCN(CC1=O)c1cnc2c(ccc(F)c2c1)C(=O)Nc1cnccc1[C@@H]1C[C@H](C)C[C@H](N)C1

InChI Key: InChIKey=NTRCYVMXMREWKA-ZCNNSNEGSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 376784   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM376784 (N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...) Show SMILES CC(C)N1CCN(CC1=O)c1cnc2c(ccc(F)c2c1)C(=O)Nc1cnccc1[C@@H]1C[C@H](C)C[C@H](N)C1 |r| Show InChI InChI=1S/C29H35FN6O2/c1-17(2)36-9-8-35(16-27(36)37)21-13-24-25(30)5-4-23(28(24)33-14-21)29(38)34-26-15-32-7-6-22(26)19-10-18(3)11-20(31)12-19/h4-7,13-15,17-20H,8-12,16,31H2,1-3H3,(H,34,38)/t18-,19+,20-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
Montana State University					Assay Description Pim-1 and Pim-3 kinase assays—20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...				J Med Chem 50: 4928-38 (2007) BindingDB Entry DOI: 10.7270/Q20G3NF8
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-2 (Homo sapiens (Human))	BDBM376784 (N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...) Show SMILES CC(C)N1CCN(CC1=O)c1cnc2c(ccc(F)c2c1)C(=O)Nc1cnccc1[C@@H]1C[C@H](C)C[C@H](N)C1 |r| Show InChI InChI=1S/C29H35FN6O2/c1-17(2)36-9-8-35(16-27(36)37)21-13-24-25(30)5-4-23(28(24)33-14-21)29(38)34-26-15-32-7-6-22(26)19-10-18(3)11-20(31)12-19/h4-7,13-15,17-20H,8-12,16,31H2,1-3H3,(H,34,38)/t18-,19+,20-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Montana State University					Assay Description Pim-2 kinase assay—20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay buffer (50 m...				J Med Chem 50: 4928-38 (2007) BindingDB Entry DOI: 10.7270/Q20G3NF8
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-3 (Homo sapiens (Human))	BDBM376784 (N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...) Show SMILES CC(C)N1CCN(CC1=O)c1cnc2c(ccc(F)c2c1)C(=O)Nc1cnccc1[C@@H]1C[C@H](C)C[C@H](N)C1 |r| Show InChI InChI=1S/C29H35FN6O2/c1-17(2)36-9-8-35(16-27(36)37)21-13-24-25(30)5-4-23(28(24)33-14-21)29(38)34-26-15-32-7-6-22(26)19-10-18(3)11-20(31)12-19/h4-7,13-15,17-20H,8-12,16,31H2,1-3H3,(H,34,38)/t18-,19+,20-/m0/s1	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
Montana State University					Assay Description Pim-1 and Pim-3 kinase assays—20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...				J Med Chem 50: 4928-38 (2007) BindingDB Entry DOI: 10.7270/Q20G3NF8
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM376784 (N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...) Show SMILES CC(C)N1CCN(CC1=O)c1cnc2c(ccc(F)c2c1)C(=O)Nc1cnccc1[C@@H]1C[C@H](C)C[C@H](N)C1 |r| Show InChI InChI=1S/C29H35FN6O2/c1-17(2)36-9-8-35(16-27(36)37)21-13-24-25(30)5-4-23(28(24)33-14-21)29(38)34-26-15-32-7-6-22(26)19-10-18(3)11-20(31)12-19/h4-7,13-15,17-20H,8-12,16,31H2,1-3H3,(H,34,38)/t18-,19+,20-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories					Assay Description Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...				J Med Chem 50: 641-62 (2007) BindingDB Entry DOI: 10.7270/Q2MP55J7
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-3 (Homo sapiens (Human))	BDBM376784 (N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...) Show SMILES CC(C)N1CCN(CC1=O)c1cnc2c(ccc(F)c2c1)C(=O)Nc1cnccc1[C@@H]1C[C@H](C)C[C@H](N)C1 |r| Show InChI InChI=1S/C29H35FN6O2/c1-17(2)36-9-8-35(16-27(36)37)21-13-24-25(30)5-4-23(28(24)33-14-21)29(38)34-26-15-32-7-6-22(26)19-10-18(3)11-20(31)12-19/h4-7,13-15,17-20H,8-12,16,31H2,1-3H3,(H,34,38)/t18-,19+,20-/m0/s1	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...				Citation and Details BindingDB Entry DOI: 10.7270/Q20V8GZM
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-3 (Homo sapiens (Human))	BDBM376784 (N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...) Show SMILES CC(C)N1CCN(CC1=O)c1cnc2c(ccc(F)c2c1)C(=O)Nc1cnccc1[C@@H]1C[C@H](C)C[C@H](N)C1 |r| Show InChI InChI=1S/C29H35FN6O2/c1-17(2)36-9-8-35(16-27(36)37)21-13-24-25(30)5-4-23(28(24)33-14-21)29(38)34-26-15-32-7-6-22(26)19-10-18(3)11-20(31)12-19/h4-7,13-15,17-20H,8-12,16,31H2,1-3H3,(H,34,38)/t18-,19+,20-/m0/s1	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories					Assay Description Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...				J Med Chem 50: 641-62 (2007) BindingDB Entry DOI: 10.7270/Q2MP55J7
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM376784 (N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...) Show SMILES CC(C)N1CCN(CC1=O)c1cnc2c(ccc(F)c2c1)C(=O)Nc1cnccc1[C@@H]1C[C@H](C)C[C@H](N)C1 |r| Show InChI InChI=1S/C29H35FN6O2/c1-17(2)36-9-8-35(16-27(36)37)21-13-24-25(30)5-4-23(28(24)33-14-21)29(38)34-26-15-32-7-6-22(26)19-10-18(3)11-20(31)12-19/h4-7,13-15,17-20H,8-12,16,31H2,1-3H3,(H,34,38)/t18-,19+,20-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...				Citation and Details BindingDB Entry DOI: 10.7270/Q20V8GZM
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-2 (Homo sapiens (Human))	BDBM376784 (N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...) Show SMILES CC(C)N1CCN(CC1=O)c1cnc2c(ccc(F)c2c1)C(=O)Nc1cnccc1[C@@H]1C[C@H](C)C[C@H](N)C1 |r| Show InChI InChI=1S/C29H35FN6O2/c1-17(2)36-9-8-35(16-27(36)37)21-13-24-25(30)5-4-23(28(24)33-14-21)29(38)34-26-15-32-7-6-22(26)19-10-18(3)11-20(31)12-19/h4-7,13-15,17-20H,8-12,16,31H2,1-3H3,(H,34,38)/t18-,19+,20-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...				Citation and Details BindingDB Entry DOI: 10.7270/Q20V8GZM
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-2 (Homo sapiens (Human))	BDBM376784 (N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...) Show SMILES CC(C)N1CCN(CC1=O)c1cnc2c(ccc(F)c2c1)C(=O)Nc1cnccc1[C@@H]1C[C@H](C)C[C@H](N)C1 |r| Show InChI InChI=1S/C29H35FN6O2/c1-17(2)36-9-8-35(16-27(36)37)21-13-24-25(30)5-4-23(28(24)33-14-21)29(38)34-26-15-32-7-6-22(26)19-10-18(3)11-20(31)12-19/h4-7,13-15,17-20H,8-12,16,31H2,1-3H3,(H,34,38)/t18-,19+,20-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories					Assay Description Pim-2 kinase assay-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay buffer (50 m...				J Med Chem 50: 641-62 (2007) BindingDB Entry DOI: 10.7270/Q2MP55J7
					More data for this Ligand-Target Pair