null

SMILES: C[C@@H]1C[C@H](N)C[C@@H](C1)c1ccncc1NC(=O)c1ccc(F)c2cc(cnc12)N1CC(C)(C)C1

InChI Key: InChIKey=HGXZUJZPHSTCIH-KSZLIROESA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 376785   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM376785 (N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...) Show SMILES C[C@@H]1C[C@H](N)C[C@@H](C1)c1ccncc1NC(=O)c1ccc(F)c2cc(cnc12)N1CC(C)(C)C1 |r| Show InChI InChI=1S/C27H32FN5O/c1-16-8-17(10-18(29)9-16)20-6-7-30-13-24(20)32-26(34)21-4-5-23(28)22-11-19(12-31-25(21)22)33-14-27(2,3)15-33/h4-7,11-13,16-18H,8-10,14-15,29H2,1-3H3,(H,32,34)/t16-,17+,18-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
Montana State University					Assay Description Pim-1 and Pim-3 kinase assays—20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...				J Med Chem 50: 4928-38 (2007) BindingDB Entry DOI: 10.7270/Q20G3NF8
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-2 (Homo sapiens (Human))	BDBM376785 (N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...) Show SMILES C[C@@H]1C[C@H](N)C[C@@H](C1)c1ccncc1NC(=O)c1ccc(F)c2cc(cnc12)N1CC(C)(C)C1 |r| Show InChI InChI=1S/C27H32FN5O/c1-16-8-17(10-18(29)9-16)20-6-7-30-13-24(20)32-26(34)21-4-5-23(28)22-11-19(12-31-25(21)22)33-14-27(2,3)15-33/h4-7,11-13,16-18H,8-10,14-15,29H2,1-3H3,(H,32,34)/t16-,17+,18-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Montana State University					Assay Description Pim-2 kinase assay—20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay buffer (50 m...				J Med Chem 50: 4928-38 (2007) BindingDB Entry DOI: 10.7270/Q20G3NF8
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-3 (Homo sapiens (Human))	BDBM376785 (N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...) Show SMILES C[C@@H]1C[C@H](N)C[C@@H](C1)c1ccncc1NC(=O)c1ccc(F)c2cc(cnc12)N1CC(C)(C)C1 |r| Show InChI InChI=1S/C27H32FN5O/c1-16-8-17(10-18(29)9-16)20-6-7-30-13-24(20)32-26(34)21-4-5-23(28)22-11-19(12-31-25(21)22)33-14-27(2,3)15-33/h4-7,11-13,16-18H,8-10,14-15,29H2,1-3H3,(H,32,34)/t16-,17+,18-/m0/s1	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
Montana State University					Assay Description Pim-1 and Pim-3 kinase assays—20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...				J Med Chem 50: 4928-38 (2007) BindingDB Entry DOI: 10.7270/Q20G3NF8
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM376785 (N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...) Show SMILES C[C@@H]1C[C@H](N)C[C@@H](C1)c1ccncc1NC(=O)c1ccc(F)c2cc(cnc12)N1CC(C)(C)C1 |r| Show InChI InChI=1S/C27H32FN5O/c1-16-8-17(10-18(29)9-16)20-6-7-30-13-24(20)32-26(34)21-4-5-23(28)22-11-19(12-31-25(21)22)33-14-27(2,3)15-33/h4-7,11-13,16-18H,8-10,14-15,29H2,1-3H3,(H,32,34)/t16-,17+,18-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories					Assay Description Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...				J Med Chem 50: 641-62 (2007) BindingDB Entry DOI: 10.7270/Q2MP55J7
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-3 (Homo sapiens (Human))	BDBM376785 (N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...) Show SMILES C[C@@H]1C[C@H](N)C[C@@H](C1)c1ccncc1NC(=O)c1ccc(F)c2cc(cnc12)N1CC(C)(C)C1 |r| Show InChI InChI=1S/C27H32FN5O/c1-16-8-17(10-18(29)9-16)20-6-7-30-13-24(20)32-26(34)21-4-5-23(28)22-11-19(12-31-25(21)22)33-14-27(2,3)15-33/h4-7,11-13,16-18H,8-10,14-15,29H2,1-3H3,(H,32,34)/t16-,17+,18-/m0/s1	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...				Citation and Details BindingDB Entry DOI: 10.7270/Q20V8GZM
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-3 (Homo sapiens (Human))	BDBM376785 (N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...) Show SMILES C[C@@H]1C[C@H](N)C[C@@H](C1)c1ccncc1NC(=O)c1ccc(F)c2cc(cnc12)N1CC(C)(C)C1 |r| Show InChI InChI=1S/C27H32FN5O/c1-16-8-17(10-18(29)9-16)20-6-7-30-13-24(20)32-26(34)21-4-5-23(28)22-11-19(12-31-25(21)22)33-14-27(2,3)15-33/h4-7,11-13,16-18H,8-10,14-15,29H2,1-3H3,(H,32,34)/t16-,17+,18-/m0/s1	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories					Assay Description Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...				J Med Chem 50: 641-62 (2007) BindingDB Entry DOI: 10.7270/Q2MP55J7
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM376785 (N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...) Show SMILES C[C@@H]1C[C@H](N)C[C@@H](C1)c1ccncc1NC(=O)c1ccc(F)c2cc(cnc12)N1CC(C)(C)C1 |r| Show InChI InChI=1S/C27H32FN5O/c1-16-8-17(10-18(29)9-16)20-6-7-30-13-24(20)32-26(34)21-4-5-23(28)22-11-19(12-31-25(21)22)33-14-27(2,3)15-33/h4-7,11-13,16-18H,8-10,14-15,29H2,1-3H3,(H,32,34)/t16-,17+,18-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...				Citation and Details BindingDB Entry DOI: 10.7270/Q20V8GZM
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-2 (Homo sapiens (Human))	BDBM376785 (N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...) Show SMILES C[C@@H]1C[C@H](N)C[C@@H](C1)c1ccncc1NC(=O)c1ccc(F)c2cc(cnc12)N1CC(C)(C)C1 |r| Show InChI InChI=1S/C27H32FN5O/c1-16-8-17(10-18(29)9-16)20-6-7-30-13-24(20)32-26(34)21-4-5-23(28)22-11-19(12-31-25(21)22)33-14-27(2,3)15-33/h4-7,11-13,16-18H,8-10,14-15,29H2,1-3H3,(H,32,34)/t16-,17+,18-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...				Citation and Details BindingDB Entry DOI: 10.7270/Q20V8GZM
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-2 (Homo sapiens (Human))	BDBM376785 (N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...) Show SMILES C[C@@H]1C[C@H](N)C[C@@H](C1)c1ccncc1NC(=O)c1ccc(F)c2cc(cnc12)N1CC(C)(C)C1 |r| Show InChI InChI=1S/C27H32FN5O/c1-16-8-17(10-18(29)9-16)20-6-7-30-13-24(20)32-26(34)21-4-5-23(28)22-11-19(12-31-25(21)22)33-14-27(2,3)15-33/h4-7,11-13,16-18H,8-10,14-15,29H2,1-3H3,(H,32,34)/t16-,17+,18-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories					Assay Description Pim-2 kinase assay-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay buffer (50 m...				J Med Chem 50: 641-62 (2007) BindingDB Entry DOI: 10.7270/Q2MP55J7
					More data for this Ligand-Target Pair