null

SMILES: CO[C@H]1CCN([C@H](C)C1)c1cnc2c(ccc(F)c2c1)C(=O)Nc1cnccc1[C@@H]1C[C@H](C)C[C@H](N)C1

InChI Key: InChIKey=IPJPUTUSUZLVEP-MOFJNDHNSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 376828   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM376828 (N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...) Show SMILES CO[C@H]1CCN([C@H](C)C1)c1cnc2c(ccc(F)c2c1)C(=O)Nc1cnccc1[C@@H]1C[C@H](C)C[C@H](N)C1 |r| Show InChI InChI=1S/C29H36FN5O2/c1-17-10-19(13-20(31)11-17)23-6-8-32-16-27(23)34-29(36)24-4-5-26(30)25-14-21(15-33-28(24)25)35-9-7-22(37-3)12-18(35)2/h4-6,8,14-20,22H,7,9-13,31H2,1-3H3,(H,34,36)/t17-,18+,19+,20-,22-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
Montana State University					Assay Description Pim-1 and Pim-3 kinase assays—20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...				J Med Chem 50: 4928-38 (2007) BindingDB Entry DOI: 10.7270/Q20G3NF8
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-2 (Homo sapiens (Human))	BDBM376828 (N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...) Show SMILES CO[C@H]1CCN([C@H](C)C1)c1cnc2c(ccc(F)c2c1)C(=O)Nc1cnccc1[C@@H]1C[C@H](C)C[C@H](N)C1 |r| Show InChI InChI=1S/C29H36FN5O2/c1-17-10-19(13-20(31)11-17)23-6-8-32-16-27(23)34-29(36)24-4-5-26(30)25-14-21(15-33-28(24)25)35-9-7-22(37-3)12-18(35)2/h4-6,8,14-20,22H,7,9-13,31H2,1-3H3,(H,34,36)/t17-,18+,19+,20-,22-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Montana State University					Assay Description Pim-2 kinase assay—20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay buffer (50 m...				J Med Chem 50: 4928-38 (2007) BindingDB Entry DOI: 10.7270/Q20G3NF8
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-3 (Homo sapiens (Human))	BDBM376828 (N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...) Show SMILES CO[C@H]1CCN([C@H](C)C1)c1cnc2c(ccc(F)c2c1)C(=O)Nc1cnccc1[C@@H]1C[C@H](C)C[C@H](N)C1 |r| Show InChI InChI=1S/C29H36FN5O2/c1-17-10-19(13-20(31)11-17)23-6-8-32-16-27(23)34-29(36)24-4-5-26(30)25-14-21(15-33-28(24)25)35-9-7-22(37-3)12-18(35)2/h4-6,8,14-20,22H,7,9-13,31H2,1-3H3,(H,34,36)/t17-,18+,19+,20-,22-/m0/s1	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
Montana State University					Assay Description Pim-1 and Pim-3 kinase assays—20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...				J Med Chem 50: 4928-38 (2007) BindingDB Entry DOI: 10.7270/Q20G3NF8
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM376828 (N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...) Show SMILES CO[C@H]1CCN([C@H](C)C1)c1cnc2c(ccc(F)c2c1)C(=O)Nc1cnccc1[C@@H]1C[C@H](C)C[C@H](N)C1 |r| Show InChI InChI=1S/C29H36FN5O2/c1-17-10-19(13-20(31)11-17)23-6-8-32-16-27(23)34-29(36)24-4-5-26(30)25-14-21(15-33-28(24)25)35-9-7-22(37-3)12-18(35)2/h4-6,8,14-20,22H,7,9-13,31H2,1-3H3,(H,34,36)/t17-,18+,19+,20-,22-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories					Assay Description Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...				J Med Chem 50: 641-62 (2007) BindingDB Entry DOI: 10.7270/Q2MP55J7
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-3 (Homo sapiens (Human))	BDBM376828 (N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...) Show SMILES CO[C@H]1CCN([C@H](C)C1)c1cnc2c(ccc(F)c2c1)C(=O)Nc1cnccc1[C@@H]1C[C@H](C)C[C@H](N)C1 |r| Show InChI InChI=1S/C29H36FN5O2/c1-17-10-19(13-20(31)11-17)23-6-8-32-16-27(23)34-29(36)24-4-5-26(30)25-14-21(15-33-28(24)25)35-9-7-22(37-3)12-18(35)2/h4-6,8,14-20,22H,7,9-13,31H2,1-3H3,(H,34,36)/t17-,18+,19+,20-,22-/m0/s1	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-3 (Homo sapiens (Human))	BDBM376828 (N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...) Show SMILES CO[C@H]1CCN([C@H](C)C1)c1cnc2c(ccc(F)c2c1)C(=O)Nc1cnccc1[C@@H]1C[C@H](C)C[C@H](N)C1 |r| Show InChI InChI=1S/C29H36FN5O2/c1-17-10-19(13-20(31)11-17)23-6-8-32-16-27(23)34-29(36)24-4-5-26(30)25-14-21(15-33-28(24)25)35-9-7-22(37-3)12-18(35)2/h4-6,8,14-20,22H,7,9-13,31H2,1-3H3,(H,34,36)/t17-,18+,19+,20-,22-/m0/s1	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories					Assay Description Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...				J Med Chem 50: 641-62 (2007) BindingDB Entry DOI: 10.7270/Q2MP55J7
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM376828 (N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...) Show SMILES CO[C@H]1CCN([C@H](C)C1)c1cnc2c(ccc(F)c2c1)C(=O)Nc1cnccc1[C@@H]1C[C@H](C)C[C@H](N)C1 |r| Show InChI InChI=1S/C29H36FN5O2/c1-17-10-19(13-20(31)11-17)23-6-8-32-16-27(23)34-29(36)24-4-5-26(30)25-14-21(15-33-28(24)25)35-9-7-22(37-3)12-18(35)2/h4-6,8,14-20,22H,7,9-13,31H2,1-3H3,(H,34,36)/t17-,18+,19+,20-,22-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-2 (Homo sapiens (Human))	BDBM376828 (N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...) Show SMILES CO[C@H]1CCN([C@H](C)C1)c1cnc2c(ccc(F)c2c1)C(=O)Nc1cnccc1[C@@H]1C[C@H](C)C[C@H](N)C1 |r| Show InChI InChI=1S/C29H36FN5O2/c1-17-10-19(13-20(31)11-17)23-6-8-32-16-27(23)34-29(36)24-4-5-26(30)25-14-21(15-33-28(24)25)35-9-7-22(37-3)12-18(35)2/h4-6,8,14-20,22H,7,9-13,31H2,1-3H3,(H,34,36)/t17-,18+,19+,20-,22-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-2 (Homo sapiens (Human))	BDBM376828 (N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...) Show SMILES CO[C@H]1CCN([C@H](C)C1)c1cnc2c(ccc(F)c2c1)C(=O)Nc1cnccc1[C@@H]1C[C@H](C)C[C@H](N)C1 |r| Show InChI InChI=1S/C29H36FN5O2/c1-17-10-19(13-20(31)11-17)23-6-8-32-16-27(23)34-29(36)24-4-5-26(30)25-14-21(15-33-28(24)25)35-9-7-22(37-3)12-18(35)2/h4-6,8,14-20,22H,7,9-13,31H2,1-3H3,(H,34,36)/t17-,18+,19+,20-,22-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories					Assay Description Pim-2 kinase assay-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay buffer (50 m...				J Med Chem 50: 641-62 (2007) BindingDB Entry DOI: 10.7270/Q2MP55J7
					More data for this Ligand-Target Pair