null

SMILES: C[C@@H]1C[C@H](N)C[C@@H](C1)c1ccncc1NC(=O)c1ccc(F)c2cc(cnc12)N1CCCC[C@H]1C

InChI Key: InChIKey=VQNYBTPYLJEXAX-NMLBUPMWSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 376838   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM376838 (N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...) Show SMILES C[C@@H]1C[C@H](N)C[C@@H](C1)c1ccncc1NC(=O)c1ccc(F)c2cc(cnc12)N1CCCC[C@H]1C |r| Show InChI InChI=1S/C28H34FN5O/c1-17-11-19(13-20(30)12-17)22-8-9-31-16-26(22)33-28(35)23-6-7-25(29)24-14-21(15-32-27(23)24)34-10-4-3-5-18(34)2/h6-9,14-20H,3-5,10-13,30H2,1-2H3,(H,33,35)/t17-,18+,19+,20-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
Montana State University					Assay Description Pim-1 and Pim-3 kinase assays—20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...				J Med Chem 50: 4928-38 (2007) BindingDB Entry DOI: 10.7270/Q20G3NF8
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-2 (Homo sapiens (Human))	BDBM376838 (N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...) Show SMILES C[C@@H]1C[C@H](N)C[C@@H](C1)c1ccncc1NC(=O)c1ccc(F)c2cc(cnc12)N1CCCC[C@H]1C |r| Show InChI InChI=1S/C28H34FN5O/c1-17-11-19(13-20(30)12-17)22-8-9-31-16-26(22)33-28(35)23-6-7-25(29)24-14-21(15-32-27(23)24)34-10-4-3-5-18(34)2/h6-9,14-20H,3-5,10-13,30H2,1-2H3,(H,33,35)/t17-,18+,19+,20-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Montana State University					Assay Description Pim-2 kinase assay—20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay buffer (50 m...				J Med Chem 50: 4928-38 (2007) BindingDB Entry DOI: 10.7270/Q20G3NF8
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-3 (Homo sapiens (Human))	BDBM376838 (N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...) Show SMILES C[C@@H]1C[C@H](N)C[C@@H](C1)c1ccncc1NC(=O)c1ccc(F)c2cc(cnc12)N1CCCC[C@H]1C |r| Show InChI InChI=1S/C28H34FN5O/c1-17-11-19(13-20(30)12-17)22-8-9-31-16-26(22)33-28(35)23-6-7-25(29)24-14-21(15-32-27(23)24)34-10-4-3-5-18(34)2/h6-9,14-20H,3-5,10-13,30H2,1-2H3,(H,33,35)/t17-,18+,19+,20-/m0/s1	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
Montana State University					Assay Description Pim-1 and Pim-3 kinase assays—20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...				J Med Chem 50: 4928-38 (2007) BindingDB Entry DOI: 10.7270/Q20G3NF8
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM376838 (N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...) Show SMILES C[C@@H]1C[C@H](N)C[C@@H](C1)c1ccncc1NC(=O)c1ccc(F)c2cc(cnc12)N1CCCC[C@H]1C |r| Show InChI InChI=1S/C28H34FN5O/c1-17-11-19(13-20(30)12-17)22-8-9-31-16-26(22)33-28(35)23-6-7-25(29)24-14-21(15-32-27(23)24)34-10-4-3-5-18(34)2/h6-9,14-20H,3-5,10-13,30H2,1-2H3,(H,33,35)/t17-,18+,19+,20-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories					Assay Description Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...				J Med Chem 50: 641-62 (2007) BindingDB Entry DOI: 10.7270/Q2MP55J7
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-3 (Homo sapiens (Human))	BDBM376838 (N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...) Show SMILES C[C@@H]1C[C@H](N)C[C@@H](C1)c1ccncc1NC(=O)c1ccc(F)c2cc(cnc12)N1CCCC[C@H]1C |r| Show InChI InChI=1S/C28H34FN5O/c1-17-11-19(13-20(30)12-17)22-8-9-31-16-26(22)33-28(35)23-6-7-25(29)24-14-21(15-32-27(23)24)34-10-4-3-5-18(34)2/h6-9,14-20H,3-5,10-13,30H2,1-2H3,(H,33,35)/t17-,18+,19+,20-/m0/s1	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-3 (Homo sapiens (Human))	BDBM376838 (N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...) Show SMILES C[C@@H]1C[C@H](N)C[C@@H](C1)c1ccncc1NC(=O)c1ccc(F)c2cc(cnc12)N1CCCC[C@H]1C |r| Show InChI InChI=1S/C28H34FN5O/c1-17-11-19(13-20(30)12-17)22-8-9-31-16-26(22)33-28(35)23-6-7-25(29)24-14-21(15-32-27(23)24)34-10-4-3-5-18(34)2/h6-9,14-20H,3-5,10-13,30H2,1-2H3,(H,33,35)/t17-,18+,19+,20-/m0/s1	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories					Assay Description Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...				J Med Chem 50: 641-62 (2007) BindingDB Entry DOI: 10.7270/Q2MP55J7
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM376838 (N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...) Show SMILES C[C@@H]1C[C@H](N)C[C@@H](C1)c1ccncc1NC(=O)c1ccc(F)c2cc(cnc12)N1CCCC[C@H]1C |r| Show InChI InChI=1S/C28H34FN5O/c1-17-11-19(13-20(30)12-17)22-8-9-31-16-26(22)33-28(35)23-6-7-25(29)24-14-21(15-32-27(23)24)34-10-4-3-5-18(34)2/h6-9,14-20H,3-5,10-13,30H2,1-2H3,(H,33,35)/t17-,18+,19+,20-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-2 (Homo sapiens (Human))	BDBM376838 (N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...) Show SMILES C[C@@H]1C[C@H](N)C[C@@H](C1)c1ccncc1NC(=O)c1ccc(F)c2cc(cnc12)N1CCCC[C@H]1C |r| Show InChI InChI=1S/C28H34FN5O/c1-17-11-19(13-20(30)12-17)22-8-9-31-16-26(22)33-28(35)23-6-7-25(29)24-14-21(15-32-27(23)24)34-10-4-3-5-18(34)2/h6-9,14-20H,3-5,10-13,30H2,1-2H3,(H,33,35)/t17-,18+,19+,20-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-2 (Homo sapiens (Human))	BDBM376838 (N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridi...) Show SMILES C[C@@H]1C[C@H](N)C[C@@H](C1)c1ccncc1NC(=O)c1ccc(F)c2cc(cnc12)N1CCCC[C@H]1C |r| Show InChI InChI=1S/C28H34FN5O/c1-17-11-19(13-20(30)12-17)22-8-9-31-16-26(22)33-28(35)23-6-7-25(29)24-14-21(15-32-27(23)24)34-10-4-3-5-18(34)2/h6-9,14-20H,3-5,10-13,30H2,1-2H3,(H,33,35)/t17-,18+,19+,20-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories					Assay Description Pim-2 kinase assay-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay buffer (50 m...				J Med Chem 50: 641-62 (2007) BindingDB Entry DOI: 10.7270/Q2MP55J7
					More data for this Ligand-Target Pair