BDBM376932 US10329300, Example 26::US9920060, 26

SMILES: CN(C)C(=O)Oc1ccc(NC(=O)c2nn([C@@H]3CCCN(C3)C(=O)C=C)c3ncnc(N)c23)c(C)c1

InChI Key: InChIKey=YHIHQBUEAKTLNG-OAHLLOKOSA-N

Data: 2 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 376932   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Receptor tyrosine-protein kinase erbB-2 (Homo sapiens (Human))	BDBM376932 (US10329300, Example 26 | US9920060, 26) Show SMILES CN(C)C(=O)Oc1ccc(NC(=O)c2nn([C@@H]3CCCN(C3)C(=O)C=C)c3ncnc(N)c23)c(C)c1 Show InChI InChI=1S/C24H28N8O4/c1-5-18(33)31-10-6-7-15(12-31)32-22-19(21(25)26-13-27-22)20(29-32)23(34)28-17-9-8-16(11-14(17)2)36-24(35)30(3)4/h5,8-9,11,13,15H,1,6-7,10,12H2,2-4H3,(H,28,34)(H2,25,26,27)/t15-/m1/s1	PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
TAIHO PHARMACEUTICAL CO., LTD. US Patent					Assay Description For setting the conditions for the method for measuring the in vitro inhibitory activity of a compound against HER2-phosphorylating activity, Profile...				US Patent US10329300 (2019) BindingDB Entry DOI: 10.7270/Q2MG7RWF
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Receptor tyrosine-protein kinase erbB-2 (Homo sapiens (Human))	BDBM376932 (US10329300, Example 26 | US9920060, 26) Show SMILES CN(C)C(=O)Oc1ccc(NC(=O)c2nn([C@@H]3CCCN(C3)C(=O)C=C)c3ncnc(N)c23)c(C)c1 Show InChI InChI=1S/C24H28N8O4/c1-5-18(33)31-10-6-7-15(12-31)32-22-19(21(25)26-13-27-22)20(29-32)23(34)28-17-9-8-16(11-14(17)2)36-24(35)30(3)4/h5,8-9,11,13,15H,1,6-7,10,12H2,2-4H3,(H,28,34)(H2,25,26,27)/t15-/m1/s1	PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
Universite Paris 7-Denis Diderot					Assay Description For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...				Bioorg Med Chem 16: 1242-53 (2008) BindingDB Entry DOI: 10.7270/Q2BR8VHD
					More data for this Ligand-Target Pair