BDBM377064 US10259818, Example 46::US9944646, Example 46

SMILES: CC(c1cc(Cl)c(C#N)c2CN(CCOc12)C1CN(C1)C(C)=O)n1nc(C)c2c(N)ncnc12

InChI Key: InChIKey=HZJHOJMJVLIYQH-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 377064   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM377064 (US10259818, Example 46 | US9944646, Example 46) Show SMILES CC(c1cc(Cl)c(C#N)c2CN(CCOc12)C1CN(C1)C(C)=O)n1nc(C)c2c(N)ncnc12 Show InChI InChI=1S/C23H25ClN8O2/c1-12-20-22(26)27-11-28-23(20)32(29-12)13(2)16-6-19(24)17(7-25)18-10-30(4-5-34-21(16)18)15-8-31(9-15)14(3)33/h6,11,13,15H,4-5,8-10H2,1-3H3,(H2,26,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Curacyte Chemistry GmbH					Assay Description [γ-33P]ATP (10mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...				J Med Chem 49: 4116-26 (2006) BindingDB Entry DOI: 10.7270/Q2Q242JB
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM377064 (US10259818, Example 46 | US9944646, Example 46) Show SMILES CC(c1cc(Cl)c(C#N)c2CN(CCOc12)C1CN(C1)C(C)=O)n1nc(C)c2c(N)ncnc12 Show InChI InChI=1S/C23H25ClN8O2/c1-12-20-22(26)27-11-28-23(20)32(29-12)13(2)16-6-19(24)17(7-25)18-10-30(4-5-34-21(16)18)15-8-31(9-15)14(3)33/h6,11,13,15H,4-5,8-10H2,1-3H3,(H2,26,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Universita degli Studi di Firenze					Assay Description The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μL. Inhibitor...				Bioorg Med Chem Lett 19: 1155-8 (2009) BindingDB Entry DOI: 10.7270/Q2PG1V28
					More data for this Ligand-Target Pair