BDBM377228 3-Amino-N-{4-[(3S)-3-aminopiperidin-1-yl]-7-hydroxy-6,7-dihydro-5H-cyclopenta[b]pyridin-3-yl}-6-(2,6-difluorophenyl)pyrazine-2-carboxamide::US10265307, Example 62-1::US10517858, Example 62 (Diastereoisomer 1)::US10828290, Example 62 (Diastereoisomer 1)
SMILES: N[C@H]1CCCN(C1)c1c2CC[C@H](O)c2ncc1NC(=O)c1nc(cnc1N)-c1c(F)cccc1F
InChI Key: InChIKey=HDXYGJYVVNHCFA-SGTLLEGYSA-N
Data: 9 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human)) | BDBM377228![]() (3-Amino-N-{4-[(3S)-3-aminopiperidin-1-yl]-7-hydrox...) | PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | <100 | n/a | n/a | n/a | n/a | n/a | n/a |
Curacyte Chemistry GmbH | Assay Description Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b... | J Med Chem 49: 4116-26 (2006) BindingDB Entry DOI: 10.7270/Q2FJ2K39 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase pim-2 (Homo sapiens (Human)) | BDBM377228![]() (3-Amino-N-{4-[(3S)-3-aminopiperidin-1-yl]-7-hydrox...) | PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 550 | n/a | n/a | n/a | n/a | n/a | n/a |
Curacyte Chemistry GmbH | Assay Description Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b... | J Med Chem 49: 4116-26 (2006) BindingDB Entry DOI: 10.7270/Q2FJ2K39 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase pim-3 (Homo sapiens (Human)) | BDBM377228![]() (3-Amino-N-{4-[(3S)-3-aminopiperidin-1-yl]-7-hydrox...) | KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | <100 | n/a | n/a | n/a | n/a | n/a | n/a |
Curacyte Chemistry GmbH | Assay Description Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b... | J Med Chem 49: 4116-26 (2006) BindingDB Entry DOI: 10.7270/Q2FJ2K39 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human)) | BDBM377228![]() (3-Amino-N-{4-[(3S)-3-aminopiperidin-1-yl]-7-hydrox...) | PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | <100 | n/a | n/a | n/a | n/a | n/a | n/a |
Incyte Holdings Corporation; Incyte Corporation US Patent | Assay Description Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.84 compound/DMSO in the assay buffer (... | US Patent US10517858 (2019) BindingDB Entry DOI: 10.7270/Q2XD1422 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase pim-2 (Homo sapiens (Human)) | BDBM377228![]() (3-Amino-N-{4-[(3S)-3-aminopiperidin-1-yl]-7-hydrox...) | PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 550 | n/a | n/a | n/a | n/a | n/a | n/a |
Incyte Holdings Corporation; Incyte Corporation US Patent | Assay Description Pim-2 kinase assay-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay buffer (50 m... | US Patent US10517858 (2019) BindingDB Entry DOI: 10.7270/Q2XD1422 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase pim-3 (Homo sapiens (Human)) | BDBM377228![]() (3-Amino-N-{4-[(3S)-3-aminopiperidin-1-yl]-7-hydrox...) | KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | n/a | n/a | <100 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human)) | BDBM377228![]() (3-Amino-N-{4-[(3S)-3-aminopiperidin-1-yl]-7-hydrox...) | PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | <100 | n/a | n/a | n/a | n/a | n/a | n/a |
Incyte Corporation; Incyte Holdings Corporation US Patent | Assay Description Pim-1 and Pim-3 kinase assays20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μcompound/DMSO in the assa... | US Patent US10828290 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase pim-2 (Homo sapiens (Human)) | BDBM377228![]() (3-Amino-N-{4-[(3S)-3-aminopiperidin-1-yl]-7-hydrox...) | PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 550 | n/a | n/a | n/a | n/a | n/a | n/a |
Incyte Corporation; Incyte Holdings Corporation US Patent | Assay Description Pim-1 and Pim-3 kinase assays20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μcompound/DMSO in the assa... | US Patent US10828290 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase pim-3 (Homo sapiens (Human)) | BDBM377228![]() (3-Amino-N-{4-[(3S)-3-aminopiperidin-1-yl]-7-hydrox...) | KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | <100 | n/a | n/a | n/a | n/a | n/a | n/a |
Incyte Corporation; Incyte Holdings Corporation US Patent | Assay Description Pim-1 and Pim-3 kinase assays20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μcompound/DMSO in the assa... | US Patent US10828290 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human)) | BDBM377228![]() (3-Amino-N-{4-[(3S)-3-aminopiperidin-1-yl]-7-hydrox...) | PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | n/a | n/a | <100 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase pim-2 (Homo sapiens (Human)) | BDBM377228![]() (3-Amino-N-{4-[(3S)-3-aminopiperidin-1-yl]-7-hydrox...) | PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | n/a | n/a | 550 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase pim-3 (Homo sapiens (Human)) | BDBM377228![]() (3-Amino-N-{4-[(3S)-3-aminopiperidin-1-yl]-7-hydrox...) | KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | <100 | n/a | n/a | n/a | n/a | n/a | n/a |
Incyte Holdings Corporation; Incyte Corporation US Patent | Assay Description Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.84 compound/DMSO in the assay buffer (... | US Patent US10517858 (2019) BindingDB Entry DOI: 10.7270/Q2XD1422 | |||||||||||
More data for this Ligand-Target Pair |