Compile Data Set for Download or QSAR

Found 4 hits Enz. Inhib. hit(s) with Target = 'Serine/threonine-protein kinase pim-1' and Ligand = 'BDBM377228'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM377228 (3-Amino-N-{4-[(3S)-3-aminopiperidin-1-yl]-7-hydrox...) Show SMILES N[C@H]1CCCN(C1)c1c2CC[C@H](O)c2ncc1NC(=O)c1nc(cnc1N)-c1c(F)cccc1F |r| Show InChI InChI=1S/C24H25F2N7O2/c25-14-4-1-5-15(26)19(14)16-9-30-23(28)21(31-16)24(35)32-17-10-29-20-13(6-7-18(20)34)22(17)33-8-2-3-12(27)11-33/h1,4-5,9-10,12,18,34H,2-3,6-8,11,27H2,(H2,28,30)(H,32,35)/t12-,18-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Curacyte Chemistry GmbH					Assay Description Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...				J Med Chem 49: 4116-26 (2006) BindingDB Entry DOI: 10.7270/Q2FJ2K39
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM377228 (3-Amino-N-{4-[(3S)-3-aminopiperidin-1-yl]-7-hydrox...) Show SMILES N[C@H]1CCCN(C1)c1c2CC[C@H](O)c2ncc1NC(=O)c1nc(cnc1N)-c1c(F)cccc1F |r| Show InChI InChI=1S/C24H25F2N7O2/c25-14-4-1-5-15(26)19(14)16-9-30-23(28)21(31-16)24(35)32-17-10-29-20-13(6-7-18(20)34)22(17)33-8-2-3-12(27)11-33/h1,4-5,9-10,12,18,34H,2-3,6-8,11,27H2,(H2,28,30)(H,32,35)/t12-,18-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...				Citation and Details BindingDB Entry DOI: 10.7270/Q2GB2776
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM377228 (3-Amino-N-{4-[(3S)-3-aminopiperidin-1-yl]-7-hydrox...) Show SMILES N[C@H]1CCCN(C1)c1c2CC[C@H](O)c2ncc1NC(=O)c1nc(cnc1N)-c1c(F)cccc1F |r| Show InChI InChI=1S/C24H25F2N7O2/c25-14-4-1-5-15(26)19(14)16-9-30-23(28)21(31-16)24(35)32-17-10-29-20-13(6-7-18(20)34)22(17)33-8-2-3-12(27)11-33/h1,4-5,9-10,12,18,34H,2-3,6-8,11,27H2,(H2,28,30)(H,32,35)/t12-,18-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation; Incyte Holdings Corporation US Patent					Assay Description Pim-1 and Pim-3 kinase assays—20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μcompound/DMSO in the assa...				US Patent US10828290 (2020) BindingDB Entry DOI: 10.7270/Q2TB19Z5
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM377228 (3-Amino-N-{4-[(3S)-3-aminopiperidin-1-yl]-7-hydrox...) Show SMILES N[C@H]1CCCN(C1)c1c2CC[C@H](O)c2ncc1NC(=O)c1nc(cnc1N)-c1c(F)cccc1F |r| Show InChI InChI=1S/C24H25F2N7O2/c25-14-4-1-5-15(26)19(14)16-9-30-23(28)21(31-16)24(35)32-17-10-29-20-13(6-7-18(20)34)22(17)33-8-2-3-12(27)11-33/h1,4-5,9-10,12,18,34H,2-3,6-8,11,27H2,(H2,28,30)(H,32,35)/t12-,18-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.84 compound/DMSO in the assay buffer (...				US Patent US10517858 (2019) BindingDB Entry DOI: 10.7270/Q2XD1422
					More data for this Ligand-Target Pair