BDBM377418 3-Fluoro-4-((2-vinylpyridin-4-yl)methyl)-9H-carbazole-1-carboxamide::US10266491, Example 100::US10676434, Example 100

SMILES: NC(=O)c1cc(F)c(Cc2ccnc(C=C)c2)c2c3ccccc3[nH]c12

InChI Key: InChIKey=VYDSXMVUDZRLRP-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 377418   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase BTK (Homo sapiens (Human))	BDBM377418 (3-Fluoro-4-((2-vinylpyridin-4-yl)methyl)-9H-carbaz...) Show SMILES NC(=O)c1cc(F)c(Cc2ccnc(C=C)c2)c2c3ccccc3[nH]c12 Show InChI InChI=1S/C21H16FN3O/c1-2-13-9-12(7-8-24-13)10-15-17(22)11-16(21(23)26)20-19(15)14-5-3-4-6-18(14)25-20/h2-9,11,25H,1,10H2,(H2,23,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.120	n/a	n/a	n/a	n/a	n/a	n/a
Curacyte Chemistry GmbH					Assay Description To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 μM), A...				J Med Chem 49: 4116-26 (2006) BindingDB Entry DOI: 10.7270/Q26112M3
					More data for this Ligand-Target Pair
Tyrosine-protein kinase BTK (Homo sapiens (Human))	BDBM377418 (3-Fluoro-4-((2-vinylpyridin-4-yl)methyl)-9H-carbaz...) Show SMILES NC(=O)c1cc(F)c(Cc2ccnc(C=C)c2)c2c3ccccc3[nH]c12 Show InChI InChI=1S/C21H16FN3O/c1-2-13-9-12(7-8-24-13)10-15-17(22)11-16(21(23)26)20-19(15)14-5-3-4-6-18(14)25-20/h2-9,11,25H,1,10H2,(H2,23,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	0.120	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase BTK (Homo sapiens (Human))	BDBM377418 (3-Fluoro-4-((2-vinylpyridin-4-yl)methyl)-9H-carbaz...) Show SMILES NC(=O)c1cc(F)c(Cc2ccnc(C=C)c2)c2c3ccccc3[nH]c12 Show InChI InChI=1S/C21H16FN3O/c1-2-13-9-12(7-8-24-13)10-15-17(22)11-16(21(23)26)20-19(15)14-5-3-4-6-18(14)25-20/h2-9,11,25H,1,10H2,(H2,23,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.120	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 μM), A...				US Patent US10676434 (2020)
					More data for this Ligand-Target Pair