BDBM378470 N-((3S)-1-((4-aminopiperidin-1-yl)sulfonyl)-3-methylpiperidin-4-yl)-6-chloro-2-oxoindoline-5-carboxamide::US10266526, Compound 603

SMILES: C[C@H]1CN(CCC1NC(=O)c1cc2CC(=O)Nc2cc1Cl)S(=O)(=O)N1CCC(N)CC1

InChI Key: InChIKey=MURXJAXOCIKLTB-WHUIICBVSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 378470   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Histone-lysine N-methyltransferase SMYD3 (Homo sapiens (Human))	BDBM378470 (N-((3S)-1-((4-aminopiperidin-1-yl)sulfonyl)-3-meth...) Show SMILES C[C@H]1CN(CCC1NC(=O)c1cc2CC(=O)Nc2cc1Cl)S(=O)(=O)N1CCC(N)CC1 |r| Show InChI InChI=1S/C20H28ClN5O4S/c1-12-11-26(31(29,30)25-5-2-14(22)3-6-25)7-4-17(12)24-20(28)15-8-13-9-19(27)23-18(13)10-16(15)21/h8,10,12,14,17H,2-7,9,11,22H2,1H3,(H,23,27)(H,24,28)/t12-,17?/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	8.53	n/a	n/a	n/a	n/a	n/a	n/a
ENSCMu					Assay Description The assays were all performed in a buffer consisting of 25 mM Tris-Cl pH 8.0, 1 mM TCEP, 0.005% BSG, and 0.005% Tween 20, prepared on the day of use....				Bioorg Med Chem 14: 7241-57 (2006) BindingDB Entry DOI: 10.7270/Q2DJ5HX2
					More data for this Ligand-Target Pair