BDBM378919 US10266548, Example 2-11-1::methyl 3-chloro- 4-({3-[5- methoxy-4- (pyridin-4- ylamino) pyrimidin- 2-yl]-1H-indazol- 1- yl}methyl) benzoate

SMILES: COC(=O)c1ccc(Cn2nc(-c3ncc(OC)c(Nc4ccncc4)n3)c3ccccc23)c(Cl)c1

InChI Key: InChIKey=YGEJZWNWYDVTHN-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 378919   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitotic checkpoint serine/threonine-protein kinase BUB1 (Homo sapiens (Human))	BDBM378919 (US10266548, Example 2-11-1 | methyl 3-chloro- 4-({...) Show SMILES COC(=O)c1ccc(Cn2nc(-c3ncc(OC)c(Nc4ccncc4)n3)c3ccccc23)c(Cl)c1 Show InChI InChI=1S/C26H21ClN6O3/c1-35-22-14-29-25(31-24(22)30-18-9-11-28-12-10-18)23-19-5-3-4-6-21(19)33(32-23)15-17-8-7-16(13-20(17)27)26(34)36-2/h3-14H,15H2,1-2H3,(H,28,29,30,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7.10	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical					Assay Description Bub1-inhibitory activities of compounds described in the present invention were quantified using a time-resolved fluorescence energy transfer (TR-FRE...				J Med Chem 51: 4150-69 (2008) BindingDB Entry DOI: 10.7270/Q2RV0R1M
					More data for this Ligand-Target Pair