BDBM379831 US9926281, Compound 264

SMILES: CC(CC1(NC(=O)NC1=O)c1ccccn1)C(=O)N1CCN([C@@H](C)C1)c1ccc(F)c(F)c1

InChI Key: InChIKey=LUSRDLQFGWFJPD-VZSHHBOJSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 379831   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS-5) (Homo sapiens (Human))	BDBM379831 (US9926281, Compound 264) Show SMILES CC(CC1(NC(=O)NC1=O)c1ccccn1)C(=O)N1CCN([C@@H](C)C1)c1ccc(F)c(F)c1 |r| Show InChI InChI=1S/C23H25F2N5O3/c1-14(12-23(19-5-3-4-8-26-19)21(32)27-22(33)28-23)20(31)29-9-10-30(15(2)13-29)16-6-7-17(24)18(25)11-16/h3-8,11,14-15H,9-10,12-13H2,1-2H3,(H2,27,28,32,33)/t14?,15-,23?/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	19	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago					Assay Description ADAMTS-5:Protocol 2: The basis for the assay is the cleavage of the substrate TBIS-1 (5 FAM-TEGEARGSVILLK (5TAMRA)K-NH2) (SEQ ID No 2) by human ADAMT...				J Med Chem 51: 3437-48 (2008) BindingDB Entry DOI: 10.7270/Q27S7R3T
					More data for this Ligand-Target Pair
72 kDa type IV collagenase (Homo sapiens (Human))	BDBM379831 (US9926281, Compound 264) Show SMILES CC(CC1(NC(=O)NC1=O)c1ccccn1)C(=O)N1CCN([C@@H](C)C1)c1ccc(F)c(F)c1 |r| Show InChI InChI=1S/C23H25F2N5O3/c1-14(12-23(19-5-3-4-8-26-19)21(32)27-22(33)28-23)20(31)29-9-10-30(15(2)13-29)16-6-7-17(24)18(25)11-16/h3-8,11,14-15H,9-10,12-13H2,1-2H3,(H2,27,28,32,33)/t14?,15-,23?/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago					Assay Description MMP2: Protocol 2: The basis for the assay is the cleavage of the substrate 390 MMP FRET substrate I (Anaspec, Catalog n#: AS-27076) by human MMP2 (R&...				J Med Chem 51: 3437-48 (2008) BindingDB Entry DOI: 10.7270/Q27S7R3T
					More data for this Ligand-Target Pair
Disintegrin and metalloproteinase domain-containing protein 17 (Homo sapiens (Human))	BDBM379831 (US9926281, Compound 264) Show SMILES CC(CC1(NC(=O)NC1=O)c1ccccn1)C(=O)N1CCN([C@@H](C)C1)c1ccc(F)c(F)c1 |r| Show InChI InChI=1S/C23H25F2N5O3/c1-14(12-23(19-5-3-4-8-26-19)21(32)27-22(33)28-23)20(31)29-9-10-30(15(2)13-29)16-6-7-17(24)18(25)11-16/h3-8,11,14-15H,9-10,12-13H2,1-2H3,(H2,27,28,32,33)/t14?,15-,23?/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>4.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago					Assay Description TACE:The basis for the assay is the cleavage of the substrate 5FAM-LAQAVRSSSRK-5TAMRA (SEQ ID No 3) (Anaspec, custom 34891) by human TACE (R&D SYSTEM...				J Med Chem 51: 3437-48 (2008) BindingDB Entry DOI: 10.7270/Q27S7R3T
					More data for this Ligand-Target Pair