null

SMILES: Clc1ccc2[nH]nc(C(=O)Nc3ccc(cc3)-c3n[nH]c(=O)c4ccccc34)c2c1

InChI Key: InChIKey=GTDAGEODJGACPV-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 380119   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM380119 (5-chloro-N-[4-(4-oxo- 3,4-dihydrophthalazin-1- yl)...) Show SMILES Clc1ccc2[nH]nc(C(=O)Nc3ccc(cc3)-c3n[nH]c(=O)c4ccccc34)c2c1 Show InChI InChI=1S/C22H14ClN5O2/c23-13-7-10-18-17(11-13)20(27-25-18)22(30)24-14-8-5-12(6-9-14)19-15-3-1-2-4-16(15)21(29)28-26-19/h1-11H,(H,24,30)(H,25,27)(H,28,29)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago					Assay Description The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...				J Med Chem 51: 3437-48 (2008) BindingDB Entry DOI: 10.7270/Q2445PSQ
					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 (Homo sapiens (Human))	BDBM380119 (5-chloro-N-[4-(4-oxo- 3,4-dihydrophthalazin-1- yl)...) Show SMILES Clc1ccc2[nH]nc(C(=O)Nc3ccc(cc3)-c3n[nH]c(=O)c4ccccc34)c2c1 Show InChI InChI=1S/C22H14ClN5O2/c23-13-7-10-18-17(11-13)20(27-25-18)22(30)24-14-8-5-12(6-9-14)19-15-3-1-2-4-16(15)21(29)28-26-19/h1-11H,(H,24,30)(H,25,27)(H,28,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago					Assay Description The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...				J Med Chem 51: 3437-48 (2008) BindingDB Entry DOI: 10.7270/Q2445PSQ
					More data for this Ligand-Target Pair