null

SMILES: Cc1nc(c[nH]1)C(=O)Nc1ccc(cc1)-c1n[nH]c(=O)c2ccccc12

InChI Key: InChIKey=YWTMQFORMCOXKA-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 380247   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM380247 (2-methyl-N-[4-(4-oxo- 3,4-dihydrophthalazin-1- yl)...) Show SMILES Cc1nc(c[nH]1)C(=O)Nc1ccc(cc1)-c1n[nH]c(=O)c2ccccc12 Show InChI InChI=1S/C19H15N5O2/c1-11-20-10-16(21-11)19(26)22-13-8-6-12(7-9-13)17-14-4-2-3-5-15(14)18(25)24-23-17/h2-10H,1H3,(H,20,21)(H,22,26)(H,24,25)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago					Assay Description The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...				J Med Chem 51: 3437-48 (2008) BindingDB Entry DOI: 10.7270/Q2445PSQ
					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 (Homo sapiens (Human))	BDBM380247 (2-methyl-N-[4-(4-oxo- 3,4-dihydrophthalazin-1- yl)...) Show SMILES Cc1nc(c[nH]1)C(=O)Nc1ccc(cc1)-c1n[nH]c(=O)c2ccccc12 Show InChI InChI=1S/C19H15N5O2/c1-11-20-10-16(21-11)19(26)22-13-8-6-12(7-9-13)17-14-4-2-3-5-15(14)18(25)24-23-17/h2-10H,1H3,(H,20,21)(H,22,26)(H,24,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago					Assay Description The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...				J Med Chem 51: 3437-48 (2008) BindingDB Entry DOI: 10.7270/Q2445PSQ
					More data for this Ligand-Target Pair