BindingDB logo
myBDB logout

null

SMILES: FC(F)(F)c1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3CCOCC3)c2c1

InChI Key: InChIKey=UWXFRBOBAQWHFB-SHTZXODSSA-N

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 380544   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM380544
PNG
(N-(trans-4-morpholin-4-ylcyclohexyl)- 6-(trifluoro...)
Show SMILES FC(F)(F)c1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3CCOCC3)c2c1 |r,wU:13.12,wD:16.19,(-4.85,6.19,;-3.76,5.1,;-2.27,5.5,;-3.36,6.59,;-4.16,3.61,;-5.64,3.21,;-6.04,1.73,;-4.95,.64,;-5.35,-.85,;-4.26,-1.94,;-2.78,-1.54,;-2.38,-.05,;-.89,.35,;.2,-.74,;1.69,-.35,;2.78,-1.43,;2.38,-2.92,;.89,-3.32,;-.2,-2.23,;3.47,-4.01,;3.07,-5.5,;4.16,-6.59,;5.64,-6.19,;6.04,-4.7,;4.95,-3.61,;-3.47,1.04,;-3.07,2.52,)|
Show InChI InChI=1S/C19H23F3N4O/c20-19(21,22)13-1-6-17-16(11-13)18(24-12-23-17)25-14-2-4-15(5-3-14)26-7-9-27-10-8-26/h1,6,11-12,14-15H,2-5,7-10H2,(H,23,24,25)/t14-,15-
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 15n/an/an/an/an/an/a



Moffitt Cancer Center



Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...

J Med Chem 51: 4948-56 (2008)


BindingDB Entry DOI: 10.7270/Q2GB26B4
More data for this
Ligand-Target Pair