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SMILES: Cc1ccc2ncnc(N[C@H]3CC[C@@H](CC3)NCCC(F)(F)F)c2c1

InChI Key: InChIKey=CKYJSMTXDHSKDL-HDJSIYSDSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 380575   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM380575
PNG
(US9926330, 2-28 | trans-N-(6- methylquinazolin-4-y...)
Show SMILES Cc1ccc2ncnc(N[C@H]3CC[C@@H](CC3)NCCC(F)(F)F)c2c1 |r,wU:13.16,wD:10.9,(-3.46,6.67,;-4.23,5.33,;-5.77,5.33,;-6.54,4,;-5.77,2.67,;-6.54,1.33,;-5.77,,;-4.23,,;-3.46,1.33,;-1.92,1.33,;-1.15,,;-1.92,-1.33,;-1.15,-2.67,;.39,-2.67,;1.16,-1.33,;.39,,;1.15,-4,;2.69,-4,;3.47,-5.33,;5,-5.33,;5.78,-6.67,;5.78,-4,;6.54,-5.33,;-4.23,2.67,;-3.46,4,)|
Show InChI InChI=1S/C18H23F3N4/c1-12-2-7-16-15(10-12)17(24-11-23-16)25-14-5-3-13(4-6-14)22-9-8-18(19,20)21/h2,7,10-11,13-14,22H,3-6,8-9H2,1H3,(H,23,24,25)/t13-,14-
PDB
MMDB

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n/an/a 25n/an/an/an/an/an/a



Moffitt Cancer Center



Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...

J Med Chem 51: 4948-56 (2008)


BindingDB Entry DOI: 10.7270/Q2GB26B4
More data for this
Ligand-Target Pair