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SMILES: Cc1ccc2ncnc(N[C@H]3CC[C@@H](CC3)NCC(C)(C)C)c2c1

InChI Key: InChIKey=GAEFYCDPAFEPQX-WKILWMFISA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 380576   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM380576
PNG
(US9926330, 2-29 | trans-N-(2,2- dimethylpropyl)-N'...)
Show SMILES Cc1ccc2ncnc(N[C@H]3CC[C@@H](CC3)NCC(C)(C)C)c2c1 |r,wU:13.16,wD:10.9,(-2.69,6.67,;-3.47,5.33,;-5,5.33,;-5.78,4,;-5,2.67,;-5.77,1.33,;-5,,;-3.46,,;-2.69,1.33,;-1.15,1.33,;-.38,,;-1.15,-1.33,;-.38,-2.67,;1.16,-2.67,;1.93,-1.33,;1.16,,;1.93,-4,;3.47,-4,;4.23,-5.33,;5.78,-5.33,;3.47,-6.67,;5,-6.67,;-3.46,2.67,;-2.69,4,)|
Show InChI InChI=1S/C20H30N4/c1-14-5-10-18-17(11-14)19(23-13-22-18)24-16-8-6-15(7-9-16)21-12-20(2,3)4/h5,10-11,13,15-16,21H,6-9,12H2,1-4H3,(H,22,23,24)/t15-,16-
PDB
MMDB

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US Patent
n/an/a 69n/an/an/an/an/an/a



Moffitt Cancer Center



Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...

J Med Chem 51: 4948-56 (2008)


BindingDB Entry DOI: 10.7270/Q2GB26B4
More data for this
Ligand-Target Pair