BindingDB logo
myBDB logout

null

SMILES: CN(C)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(CCO)cc12

InChI Key: InChIKey=COCIRILXULQOHP-SHTZXODSSA-N

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 380588   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM380588
PNG
(2-(4-(((trans)-4-(dimethylamino)cyclohexyl)amino)q...)
Show SMILES CN(C)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(CCO)cc12 |r,wU:6.9,wD:3.2,(-2.67,-9.24,;-2.67,-7.7,;-4,-6.93,;-1.33,-6.93,;,-7.7,;1.33,-6.93,;1.33,-5.39,;,-4.62,;-1.33,-5.39,;2.67,-4.62,;2.67,-3.08,;1.33,-2.31,;1.33,-.77,;2.67,,;4,-.77,;5.33,,;6.67,-.77,;6.67,-2.31,;8,-3.08,;8,-4.62,;9.34,-5.39,;5.33,-3.08,;4,-2.31,)|
Show InChI InChI=1S/C18H26N4O/c1-22(2)15-6-4-14(5-7-15)21-18-16-11-13(9-10-23)3-8-17(16)19-12-20-18/h3,8,11-12,14-15,23H,4-7,9-10H2,1-2H3,(H,19,20,21)/t14-,15-
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 17n/an/an/an/an/an/a



Moffitt Cancer Center



Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...

J Med Chem 51: 4948-56 (2008)


BindingDB Entry DOI: 10.7270/Q2GB26B4
More data for this
Ligand-Target Pair