BDBM380770 6-(4-chlorophenyl)-2-(3,6-dihydro-2H-pyran-4-yl)-5-(3,7-dimethyl-3H-[1,2,3]triazolo[4,5-b]pyridin-5-yl)-1-isopropyl-5,6-dihydropyrrolo[3,4-d]imidazol-4(1H)-one::US9890166, Example 160
SMILES: CC(C)n1c(nc2C(=O)N(C(c12)c1ccc(Cl)cc1)c1cc(C)c2nnn(C)c2n1)C1=CCOCC1
InChI Key: InChIKey=IMSAXOAIYFOGTR-UHFFFAOYSA-N
Data: 3 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Bromodomain-containing protein 4 (Homo sapiens (Human)) | BDBM380770 (6-(4-chlorophenyl)-2-(3,6-dihydro-2H-pyran-4-yl)-5...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <11 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen | Assay Description All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and... | Cancer Res 66: 8715-21 (2006) BindingDB Entry DOI: 10.7270/Q2TM7DFQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
CREB-binding protein (Homo sapiens (Human)) | BDBM380770 (6-(4-chlorophenyl)-2-(3,6-dihydro-2H-pyran-4-yl)-5...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | >3.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen | Assay Description In order to assess bromodomain selectivity, we set up a binding assay using the bromodomain encoded by the CREBBP gene. Compounds were tested in the ... | Cancer Res 66: 8715-21 (2006) BindingDB Entry DOI: 10.7270/Q2TM7DFQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bromodomain-containing protein 3 (Homo sapiens (Human)) | BDBM380770 (6-(4-chlorophenyl)-2-(3,6-dihydro-2H-pyran-4-yl)-5...) | PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <11 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen | Assay Description All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and... | Cancer Res 66: 8715-21 (2006) BindingDB Entry DOI: 10.7270/Q2TM7DFQ | |||||||||||
More data for this Ligand-Target Pair |