BDBM380783 N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-(4(1-methyl-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidn-2-ylamino)phenyl)acrylamide ::US9890168, Compound 1::US9890168, Compound 9
SMILES: COc1cc(N(C)CCN(C)C)c(NC(=O)C=C)cc1Nc1nc(-c2cnn(C)c2)c2cc[nH]c2n1
InChI Key: InChIKey=RGRJZPKFWSMZRB-UHFFFAOYSA-N
Data: 4 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Epidermal growth factor receptor [T790M,L858R] (Homo sapiens (Human)) | BDBM380783 (N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-4-met...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Bryn Mawr College | Assay Description The inhibitory activities on T790M/L858R double mutant EGFR kinase (Invitrogen, PV4879) and wild-type EGFR kinase (Invitrogen, PV3872) were determine... | J Med Chem 51: 1706-18 (2008) BindingDB Entry DOI: 10.7270/Q2PV6NPJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor (Homo sapiens (Human)) | BDBM380783 (N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-4-met...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Bryn Mawr College | Assay Description The inhibitory activities on T790M/L858R double mutant EGFR kinase (Invitrogen, PV4879) and wild-type EGFR kinase (Invitrogen, PV3872) were determine... | J Med Chem 51: 1706-18 (2008) BindingDB Entry DOI: 10.7270/Q2PV6NPJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor [T790M,L858R] (Homo sapiens (Human)) | BDBM380783 (N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-4-met...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 22 | n/a | n/a | n/a | n/a | n/a | n/a |
Bryn Mawr College | Assay Description The inhibitory activities on T790M/L858R double mutant EGFR kinase (Invitrogen, PV4879) and wild-type EGFR kinase (Invitrogen, PV3872) were determine... | J Med Chem 51: 1706-18 (2008) BindingDB Entry DOI: 10.7270/Q2PV6NPJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor (Homo sapiens (Human)) | BDBM380783 (N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-4-met...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 393 | n/a | n/a | n/a | n/a | n/a | n/a |
Bryn Mawr College | Assay Description The inhibitory activities on T790M/L858R double mutant EGFR kinase (Invitrogen, PV4879) and wild-type EGFR kinase (Invitrogen, PV3872) were determine... | J Med Chem 51: 1706-18 (2008) BindingDB Entry DOI: 10.7270/Q2PV6NPJ | |||||||||||
More data for this Ligand-Target Pair |