null

SMILES: COc1cc(Nc2cc(Oc3ccc(NC(=O)Nc4cc(cc(CS(C)=O)c4OC)C(C)(C)C)c4ccccc34)ccn2)cc(c1)C(=O)NCCN1CCOCC1

InChI Key: InChIKey=MCPXUGGNYXHTMJ-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 381098   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM381098 (US9890185, Example 38(u)) Show SMILES COc1cc(Nc2cc(Oc3ccc(NC(=O)Nc4cc(cc(CS(C)=O)c4OC)C(C)(C)C)c4ccccc34)ccn2)cc(c1)C(=O)NCCN1CCOCC1 Show InChI InChI=1S/C43H50N6O7S/c1-43(2,3)30-21-29(27-57(6)52)40(54-5)37(24-30)48-42(51)47-36-11-12-38(35-10-8-7-9-34(35)36)56-32-13-14-44-39(26-32)46-31-22-28(23-33(25-31)53-4)41(50)45-15-16-49-17-19-55-20-18-49/h7-14,21-26H,15-20,27H2,1-6H3,(H,44,46)(H,45,50)(H2,47,48,51)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon					Assay Description Method 1: The inhibitory activities of test compounds against the p38 MAPKα isoform (MAPK14: Invitrogen), are evaluated indirectly by determinin...				J Med Chem 51: 5680-9 (2008) BindingDB Entry DOI: 10.7270/Q2FB558N
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 alpha (Homo sapiens (Human))	BDBM381098 (US9890185, Example 38(u)) Show SMILES COc1cc(Nc2cc(Oc3ccc(NC(=O)Nc4cc(cc(CS(C)=O)c4OC)C(C)(C)C)c4ccccc34)ccn2)cc(c1)C(=O)NCCN1CCOCC1 Show InChI InChI=1S/C43H50N6O7S/c1-43(2,3)30-21-29(27-57(6)52)40(54-5)37(24-30)48-42(51)47-36-11-12-38(35-10-8-7-9-34(35)36)56-32-13-14-44-39(26-32)46-31-22-28(23-33(25-31)53-4)41(50)45-15-16-49-17-19-55-20-18-49/h7-14,21-26H,15-20,27H2,1-6H3,(H,44,46)(H,45,50)(H2,47,48,51)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.07E+3	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon					Assay Description Method 1: The inhibitory activities of compounds of the invention against the GSK 3α enzyme isoform (Invitrogen), are evaluated by determining ...				J Med Chem 51: 5680-9 (2008) BindingDB Entry DOI: 10.7270/Q2FB558N
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM381098 (US9890185, Example 38(u)) Show SMILES COc1cc(Nc2cc(Oc3ccc(NC(=O)Nc4cc(cc(CS(C)=O)c4OC)C(C)(C)C)c4ccccc34)ccn2)cc(c1)C(=O)NCCN1CCOCC1 Show InChI InChI=1S/C43H50N6O7S/c1-43(2,3)30-21-29(27-57(6)52)40(54-5)37(24-30)48-42(51)47-36-11-12-38(35-10-8-7-9-34(35)36)56-32-13-14-44-39(26-32)46-31-22-28(23-33(25-31)53-4)41(50)45-15-16-49-17-19-55-20-18-49/h7-14,21-26H,15-20,27H2,1-6H3,(H,44,46)(H,45,50)(H2,47,48,51)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon					Assay Description The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri...				J Med Chem 51: 5680-9 (2008) BindingDB Entry DOI: 10.7270/Q2FB558N
					More data for this Ligand-Target Pair