BDBM381439 4-chloro-N-(4-chlorophenyl)-1-((1- ethyl-1H-imidazol-2-yl)methyl)-3- methyl-1H-pyrazolo[3,4- b]pyridine-5-carboxamide::US10272074, Example 272

SMILES: CCn1ccnc1Cn1nc(C)c2c(Cl)c(cnc12)C(=O)Nc1ccc(Cl)cc1

InChI Key: InChIKey=XSQXKVLYMWGHFR-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 381439   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Glucocorticoid receptor (Homo sapiens (Human))	BDBM381439 (4-chloro-N-(4-chlorophenyl)-1-((1- ethyl-1H-imidaz...) Show SMILES CCn1ccnc1Cn1nc(C)c2c(Cl)c(cnc12)C(=O)Nc1ccc(Cl)cc1 Show InChI InChI=1S/C20H18Cl2N6O/c1-3-27-9-8-23-16(27)11-28-19-17(12(2)26-28)18(22)15(10-24-19)20(29)25-14-6-4-13(21)5-7-14/h4-10H,3,11H2,1-2H3,(H,25,29)	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline					Assay Description The assay was performed using H4 neuroglioma cells and using indirect immunofluorescence detection of the endogenous GR receptor. Fixative: 4% PFA. P...				J Med Chem 51: 5663-79 (2008) BindingDB Entry DOI: 10.7270/Q29P33Z7
					More data for this Ligand-Target Pair