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BDBM382137 4-(4-((4-(4-(1-cyanocyclopropyl)phenyl)-5,6-dihydro-2H-pyran-3-yl)methoxy)phenyl) butanoic Acid::US10273230, Compound of Example 48

SMILES: OC(=O)CCCc1ccc(OCC2=C(CCOC2)c2ccc(cc2)C2(CC2)C#N)cc1

InChI Key: InChIKey=GKCULFVIYLAHDX-UHFFFAOYSA-N

Data: 1 EC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 382137   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
G-protein coupled receptor 120


(Homo sapiens (Human))		BDBM382137
PNG
(4-(4-((4-(4-(1-cyanocyclopropyl)phenyl)-5,6-dihydr...)
Show SMILES OC(=O)CCCc1ccc(OCC2=C(CCOC2)c2ccc(cc2)C2(CC2)C#N)cc1 |t:12|
Show InChI InChI=1S/C26H27NO4/c27-18-26(13-14-26)22-8-6-20(7-9-22)24-12-15-30-16-21(24)17-31-23-10-4-19(5-11-23)2-1-3-25(28)29/h4-11H,1-3,12-17H2,(H,28,29)
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KEGG

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PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 2.75E+3n/an/an/an/a



IRBM/Merck



Assay Description
Beta (β) arrestin 2 Interaction Assay (BRET assay) was performed using CHO-K1 cells stably expressing the GPR120 receptor using β-galactosi...

Bioorg Med Chem Lett 18: 3456-61 (2008)


BindingDB Entry DOI: 10.7270/Q2154KBP
More data for this
Ligand-Target Pair