BDBM383195 US10278968, Compound 723::US10793535, Cmpd ID 723

SMILES: Oc1ccc(CC(=O)Nc2ccc(CCCCc3nnc(NC(=O)Cc4ccccn4)s3)nn2)cc1OC(F)(F)F

InChI Key: InChIKey=DHPBNOLWZCELSM-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 383195   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Glutamate dehydrogenase 2, mitochondrial (Human)	BDBM383195 (US10278968, Compound 723 | US10793535, Cmpd ID 723) Show SMILES Oc1ccc(CC(=O)Nc2ccc(CCCCc3nnc(NC(=O)Cc4ccccn4)s3)nn2)cc1OC(F)(F)F Show InChI InChI=1S/C26H24F3N7O4S/c27-26(28,29)40-20-13-16(8-10-19(20)37)14-22(38)31-21-11-9-17(33-34-21)5-1-2-7-24-35-36-25(41-24)32-23(39)15-18-6-3-4-12-30-18/h3-4,6,8-13,37H,1-2,5,7,14-15H2,(H,31,34,38)(H,32,36,39)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	42	n/a	n/a	n/a	n/a	n/a	n/a
Calithera Biosciences, Inc. US Patent					Assay Description Glutaminase reaction buffer was prepared [50 mM Tris-HCl pH 8.8, 150 mM K2HPO4, 0.25 mM EDTA, 0.1 mg/ml BSA (Calbiochem no. 2960), 1 mM DTT, 2 mM NAD...				US Patent US10793535 (2020)
					More data for this Ligand-Target Pair
Glutaminase kidney isoform, mitochondrial (Homo sapiens (Human))	BDBM383195 (US10278968, Compound 723 | US10793535, Cmpd ID 723) Show SMILES Oc1ccc(CC(=O)Nc2ccc(CCCCc3nnc(NC(=O)Cc4ccccn4)s3)nn2)cc1OC(F)(F)F Show InChI InChI=1S/C26H24F3N7O4S/c27-26(28,29)40-20-13-16(8-10-19(20)37)14-22(38)31-21-11-9-17(33-34-21)5-1-2-7-24-35-36-25(41-24)32-23(39)15-18-6-3-4-12-30-18/h3-4,6,8-13,37H,1-2,5,7,14-15H2,(H,31,34,38)(H,32,36,39)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	42	n/a	n/a	n/a	n/a	n/a	n/a
National Taiwan University					Assay Description Compounds were assessed for their ability to inhibit the enzymatic activity of a recombinant form of Glutaminase 1 (GAC) using a biochemical assay th...				J Med Chem 51: 5594-607 (2008) BindingDB Entry DOI: 10.7270/Q27P91QX
					More data for this Ligand-Target Pair