BDBM384323 US10590114, No. 24::US9932325, Example 22::US9932325, Example 23::US9932325, Example 24

SMILES: CCNc1nc(Nc2cn(nc2C)C2(C)CCN(C)C2=O)ncc1C(F)(F)F

InChI Key: InChIKey=SHBVGNSWZSWBOH-UHFFFAOYSA-N

Data: 6 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 384323   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Leucine-rich repeat serine/threonine-protein kinase 2 [G2019S] (Homo sapiens (Human))	BDBM384323 (US10590114, No. 24 | US11111235, No. 24 | US993232...) Show SMILES CCNc1nc(Nc2cn(nc2C)C2(C)CCN(C)C2=O)ncc1C(F)(F)F Show InChI InChI=1S/C17H22F3N7O/c1-5-21-13-11(17(18,19)20)8-22-15(24-13)23-12-9-27(25-10(12)2)16(3)6-7-26(4)14(16)28/h8-9H,5-7H2,1-4H3,(H2,21,22,23,24)	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<30	n/a	n/a	n/a	n/a	n/a	n/a
Universita degli Studi di Firenze					Assay Description Materials: LRRK2 G2019S enzyme Substrate (LRRKtide) ATP TR-FRET dilution buffer pLRRKtide antibody 384-well...				Bioorg Med Chem Lett 18: 2567-73 (2008) BindingDB Entry DOI: 10.7270/Q29G5Q4M
					More data for this Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 [G2019S] (Homo sapiens (Human))	BDBM384323 (US10590114, No. 24 | US11111235, No. 24 | US993232...) Show SMILES CCNc1nc(Nc2cn(nc2C)C2(C)CCN(C)C2=O)ncc1C(F)(F)F Show InChI InChI=1S/C17H22F3N7O/c1-5-21-13-11(17(18,19)20)8-22-15(24-13)23-12-9-27(25-10(12)2)16(3)6-7-26(4)14(16)28/h8-9H,5-7H2,1-4H3,(H2,21,22,23,24)	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<30	n/a	n/a	n/a	n/a	n/a	n/a
Universita degli Studi di Firenze					Assay Description Materials: LRRK2 G2019S enzyme Substrate (LRRKtide) ATP TR-FRET dilution buffer pLRRKtide antibody 384-well...				Bioorg Med Chem Lett 18: 2567-73 (2008) BindingDB Entry DOI: 10.7270/Q29G5Q4M
					More data for this Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 [G2019S] (Homo sapiens (Human))	BDBM384323 (US10590114, No. 24 | US11111235, No. 24 | US993232...) Show SMILES CCNc1nc(Nc2cn(nc2C)C2(C)CCN(C)C2=O)ncc1C(F)(F)F Show InChI InChI=1S/C17H22F3N7O/c1-5-21-13-11(17(18,19)20)8-22-15(24-13)23-12-9-27(25-10(12)2)16(3)6-7-26(4)14(16)28/h8-9H,5-7H2,1-4H3,(H2,21,22,23,24)	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<30	n/a	n/a	n/a	n/a	n/a	n/a
Universita degli Studi di Firenze					Assay Description Materials: LRRK2 G2019S enzyme Substrate (LRRKtide) ATP TR-FRET dilution buffer pLRRKtide antibody 384-well...				Bioorg Med Chem Lett 18: 2567-73 (2008) BindingDB Entry DOI: 10.7270/Q29G5Q4M
					More data for this Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM384323 (US10590114, No. 24 | US11111235, No. 24 | US993232...) Show SMILES CCNc1nc(Nc2cn(nc2C)C2(C)CCN(C)C2=O)ncc1C(F)(F)F Show InChI InChI=1S/C17H22F3N7O/c1-5-21-13-11(17(18,19)20)8-22-15(24-13)23-12-9-27(25-10(12)2)16(3)6-7-26(4)14(16)28/h8-9H,5-7H2,1-4H3,(H2,21,22,23,24)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<30	n/a	n/a	n/a	n/a	n/a	n/a
Denali Therapautics Inc. US Patent					Assay Description Materials: LRRK2 G2019S enzyme Substrate (LRRKtide) ATP TR-FRET dilution buffer pLRRKtide antibody 384-well...				US Patent US10590114 (2020)
					More data for this Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 [G2019S] (Homo sapiens (Human))	BDBM384323 (US10590114, No. 24 | US11111235, No. 24 | US993232...) Show SMILES CCNc1nc(Nc2cn(nc2C)C2(C)CCN(C)C2=O)ncc1C(F)(F)F Show InChI InChI=1S/C17H22F3N7O/c1-5-21-13-11(17(18,19)20)8-22-15(24-13)23-12-9-27(25-10(12)2)16(3)6-7-26(4)14(16)28/h8-9H,5-7H2,1-4H3,(H2,21,22,23,24)	PDB GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	<30	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM384323 (US10590114, No. 24 | US11111235, No. 24 | US993232...) Show SMILES CCNc1nc(Nc2cn(nc2C)C2(C)CCN(C)C2=O)ncc1C(F)(F)F Show InChI InChI=1S/C17H22F3N7O/c1-5-21-13-11(17(18,19)20)8-22-15(24-13)23-12-9-27(25-10(12)2)16(3)6-7-26(4)14(16)28/h8-9H,5-7H2,1-4H3,(H2,21,22,23,24)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<30	n/a	n/a	n/a	n/a	n/a	n/a
Denali Therapautics Inc. US Patent					Assay Description Materials: LRRK2 G2019S enzyme Substrate (LRRKtide) ATP TR-FRET dilution buffer pLRRKtide antibody 384-well...				US Patent US10590114 (2020)
					More data for this Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 [G2019S] (Homo sapiens (Human))	BDBM384323 (US10590114, No. 24 | US11111235, No. 24 | US993232...) Show SMILES CCNc1nc(Nc2cn(nc2C)C2(C)CCN(C)C2=O)ncc1C(F)(F)F Show InChI InChI=1S/C17H22F3N7O/c1-5-21-13-11(17(18,19)20)8-22-15(24-13)23-12-9-27(25-10(12)2)16(3)6-7-26(4)14(16)28/h8-9H,5-7H2,1-4H3,(H2,21,22,23,24)	PDB GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	<30	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 [G2019S] (Homo sapiens (Human))	BDBM384323 (US10590114, No. 24 | US11111235, No. 24 | US993232...) Show SMILES CCNc1nc(Nc2cn(nc2C)C2(C)CCN(C)C2=O)ncc1C(F)(F)F Show InChI InChI=1S/C17H22F3N7O/c1-5-21-13-11(17(18,19)20)8-22-15(24-13)23-12-9-27(25-10(12)2)16(3)6-7-26(4)14(16)28/h8-9H,5-7H2,1-4H3,(H2,21,22,23,24)	PDB GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	<30	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM384323 (US10590114, No. 24 | US11111235, No. 24 | US993232...) Show SMILES CCNc1nc(Nc2cn(nc2C)C2(C)CCN(C)C2=O)ncc1C(F)(F)F Show InChI InChI=1S/C17H22F3N7O/c1-5-21-13-11(17(18,19)20)8-22-15(24-13)23-12-9-27(25-10(12)2)16(3)6-7-26(4)14(16)28/h8-9H,5-7H2,1-4H3,(H2,21,22,23,24)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<30	n/a	n/a	n/a	n/a	n/a	n/a
Denali Therapautics Inc. US Patent					Assay Description Materials: LRRK2 G2019S enzyme Substrate (LRRKtide) ATP TR-FRET dilution buffer pLRRKtide antibody 384-well...				US Patent US10590114 (2020)
					More data for this Ligand-Target Pair