BDBM384761 US10285983, Compound 181

SMILES: CN(C)Cc1cncc(c1)-c1cnc2[nH]nc(-c3cc4c(ccnc4[nH]3)N3CCCCC3)c2c1

InChI Key: InChIKey=QFBOXKCCHDNCIG-UHFFFAOYSA-N

Data: 1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 384761   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Proto-oncogene Wnt-1 (Homo sapiens (human))	BDBM384761 (US10285983, Compound 181) Show SMILES CN(C)Cc1cncc(c1)-c1cnc2[nH]nc(-c3cc4c(ccnc4[nH]3)N3CCCCC3)c2c1 Show InChI InChI=1S/C26H28N8/c1-33(2)16-17-10-18(14-27-13-17)19-11-21-24(31-32-26(21)29-15-19)22-12-20-23(6-7-28-25(20)30-22)34-8-4-3-5-9-34/h6-7,10-15H,3-5,8-9,16H2,1-2H3,(H,28,30)(H,29,31,32)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a
Istanbul University					Assay Description SW480 colon carcinoma cells were transduced with a lentiviral vector expressing luciferase with a human Sp5 promoter consisting of a sequence of eigh...				Bioorg Med Chem 16: 9113-20 (2008) BindingDB Entry DOI: 10.7270/Q2D79DQJ
					More data for this Ligand-Target Pair