BDBM384885 2-(dimethylamino)-N-{(1R)-1-[3-fluoro- 4-(trifluoromethoxy)phenyl]-2,2- dimethylpropyl}-6-oxo-1,6- dihydropyrimidine-4-carboxamide::US10285989, Example 101
SMILES: CN(C)c1nc(cc(=O)[nH]1)C(=O)N[C@@H](c1ccc(OC(F)(F)F)c(F)c1)C(C)(C)C
InChI Key:
Data: 2 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
cGMP-dependent 3',5'-cyclic phosphodiesterase (Homo sapiens (Human)) | BDBM384885 (2-(dimethylamino)-N-{(1R)-1-[3-fluoro- 4-(trifluor...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.120 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company | Assay Description The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization... | Bioorg Med Chem Lett 17: 4284-9 (2007) BindingDB Entry DOI: 10.7270/Q24Q7X9Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphodiesterase (Macaca mulatta (Rhesus macaque)) | BDBM384885 (2-(dimethylamino)-N-{(1R)-1-[3-fluoro- 4-(trifluor...) | PDB UniProtKB/TrEMBL GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.140 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company | Assay Description The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization... | Bioorg Med Chem Lett 17: 4284-9 (2007) BindingDB Entry DOI: 10.7270/Q24Q7X9Z | |||||||||||
More data for this Ligand-Target Pair |