BDBM387180 5-((5-chloro-2-((1-methyl-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)amino)-N-ethylhexahydrocyclopenta[c]pyrrole-2(1H)-carboxamide::US9938257, Example 18

SMILES: CCNC(=O)N1CC2CC(CC2C1)Nc1nc(Nc2cnn(C)c2)ncc1Cl

InChI Key: InChIKey=YHTMTLWBCNPEPE-UHFFFAOYSA-N

Data: 5 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 387180   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK1 (Homo sapiens (Human))	BDBM387180 (5-((5-chloro-2-((1-methyl-1H-pyrazol-4-yl)amino)py...) Show SMILES CCNC(=O)N1CC2CC(CC2C1)Nc1nc(Nc2cnn(C)c2)ncc1Cl Show InChI InChI=1S/C18H25ClN8O/c1-3-20-18(28)27-8-11-4-13(5-12(11)9-27)23-16-15(19)7-21-17(25-16)24-14-6-22-26(2)10-14/h6-7,10-13H,3-5,8-9H2,1-2H3,(H,20,28)(H2,21,23,24,25)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description JAK1:Kinase assays can be performed by measurement of incorporation of γ-33P ATP into immobilized myelin basic protein (MBP). High binding white...				J Med Chem 51: 4632-40 (2008) BindingDB Entry DOI: 10.7270/Q2X350S7
					More data for this Ligand-Target Pair
Aurora kinase A (Homo sapiens (Human))	BDBM387180 (5-((5-chloro-2-((1-methyl-1H-pyrazol-4-yl)amino)py...) Show SMILES CCNC(=O)N1CC2CC(CC2C1)Nc1nc(Nc2cnn(C)c2)ncc1Cl Show InChI InChI=1S/C18H25ClN8O/c1-3-20-18(28)27-8-11-4-13(5-12(11)9-27)23-16-15(19)7-21-17(25-16)24-14-6-22-26(2)10-14/h6-7,10-13H,3-5,8-9H2,1-2H3,(H,20,28)(H2,21,23,24,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description Aurora-A:Kinase assays can be performed by measurement of incorporation of γ-33P ATP into immobilized myelin basic protein (MBP). High binding w...				J Med Chem 51: 4632-40 (2008) BindingDB Entry DOI: 10.7270/Q2X350S7
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM387180 (5-((5-chloro-2-((1-methyl-1H-pyrazol-4-yl)amino)py...) Show SMILES CCNC(=O)N1CC2CC(CC2C1)Nc1nc(Nc2cnn(C)c2)ncc1Cl Show InChI InChI=1S/C18H25ClN8O/c1-3-20-18(28)27-8-11-4-13(5-12(11)9-27)23-16-15(19)7-21-17(25-16)24-14-6-22-26(2)10-14/h6-7,10-13H,3-5,8-9H2,1-2H3,(H,20,28)(H2,21,23,24,25)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.03E+3	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description FLT3:Kinase assays can be performed by measurement of incorporation of γ-33P ATP into immobilized myelin basic protein (MBP). High binding white...				J Med Chem 51: 4632-40 (2008) BindingDB Entry DOI: 10.7270/Q2X350S7
					More data for this Ligand-Target Pair
Aurora kinase B (Homo sapiens (Human))	BDBM387180 (5-((5-chloro-2-((1-methyl-1H-pyrazol-4-yl)amino)py...) Show SMILES CCNC(=O)N1CC2CC(CC2C1)Nc1nc(Nc2cnn(C)c2)ncc1Cl Show InChI InChI=1S/C18H25ClN8O/c1-3-20-18(28)27-8-11-4-13(5-12(11)9-27)23-16-15(19)7-21-17(25-16)24-14-6-22-26(2)10-14/h6-7,10-13H,3-5,8-9H2,1-2H3,(H,20,28)(H2,21,23,24,25)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description Aurora-B:Kinase assays can be performed by measurement of incorporation of γ-33P ATP into immobilized myelin basic protein (MBP). High binding w...				J Med Chem 51: 4632-40 (2008) BindingDB Entry DOI: 10.7270/Q2X350S7
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM387180 (5-((5-chloro-2-((1-methyl-1H-pyrazol-4-yl)amino)py...) Show SMILES CCNC(=O)N1CC2CC(CC2C1)Nc1nc(Nc2cnn(C)c2)ncc1Cl Show InChI InChI=1S/C18H25ClN8O/c1-3-20-18(28)27-8-11-4-13(5-12(11)9-27)23-16-15(19)7-21-17(25-16)24-14-6-22-26(2)10-14/h6-7,10-13H,3-5,8-9H2,1-2H3,(H,20,28)(H2,21,23,24,25)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	142	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description JAK2:Kinase assays can be performed by measurement of incorporation of γ-33P ATP into immobilized myelin basic protein (MBP). High binding white...				J Med Chem 51: 4632-40 (2008) BindingDB Entry DOI: 10.7270/Q2X350S7
					More data for this Ligand-Target Pair