BDBM387323 1-methyl-N-[2-(pyridin-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]-1H-1,3-benzodiazol-6-amine::US10292985, Example 7

SMILES: Cn1cnc2ccc(Nc3nc(nn4cccc34)-c3ccccn3)cc12

InChI Key: InChIKey=VZTIQKAGQVINGR-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 387323   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
TGF-beta receptor type II (Homo sapiens (Human))	BDBM387323 (1-methyl-N-[2-(pyridin-2-yl)pyrrolo[2,1-f][1,2,4]t...) Show SMILES Cn1cnc2ccc(Nc3nc(nn4cccc34)-c3ccccn3)cc12 Show InChI InChI=1S/C19H15N7/c1-25-12-21-14-8-7-13(11-17(14)25)22-19-16-6-4-10-26(16)24-18(23-19)15-5-2-3-9-20-15/h2-12H,1H3,(H,22,23,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Southern California									J Med Chem 52: 20-32 (2009) BindingDB Entry DOI: 10.7270/Q28C9ZKH
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM387323 (1-methyl-N-[2-(pyridin-2-yl)pyrrolo[2,1-f][1,2,4]t...) Show SMILES Cn1cnc2ccc(Nc3nc(nn4cccc34)-c3ccccn3)cc12 Show InChI InChI=1S/C19H15N7/c1-25-12-21-14-8-7-13(11-17(14)25)22-19-16-6-4-10-26(16)24-18(23-19)15-5-2-3-9-20-15/h2-12H,1H3,(H,22,23,24)	PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	240	n/a	n/a	n/a	n/a	n/a	n/a
University of Southern California					Assay Description Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...				J Med Chem 52: 20-32 (2009) BindingDB Entry DOI: 10.7270/Q28C9ZKH
					More data for this Ligand-Target Pair