BDBM389576 N-{6-bromo-2-[(E)-2-(4- methoxyphenyl)vinyl]quinazolin-4- yl}propane-1,3-diamine::US9951029, 75

SMILES: COc1ccc(\C=C\c2nc(NCCCN)c3cc(Br)ccc3n2)cc1

InChI Key: InChIKey=RKWKRCSFCMWERQ-BJMVGYQFSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 389576   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM389576 (N-{6-bromo-2-[(E)-2-(4- methoxyphenyl)vinyl]quinaz...) Show SMILES COc1ccc(\C=C\c2nc(NCCCN)c3cc(Br)ccc3n2)cc1 Show InChI InChI=1S/C20H21BrN4O/c1-26-16-7-3-14(4-8-16)5-10-19-24-18-9-6-15(21)13-17(18)20(25-19)23-12-2-11-22/h3-10,13H,2,11-12,22H2,1H3,(H,23,24,25)/b10-5+	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	74	n/a	n/a	n/a	n/a	n/a	n/a
Georgia Institute of Technology					Assay Description FLT3(ITD) biochemical assays were performed on two different assay system platforms, using Transcreener® ADP Assay FP method (BellBrook Labs, Madison...				J Med Chem 52: 456-68 (2009) BindingDB Entry DOI: 10.7270/Q2NG4T0S
					More data for this Ligand-Target Pair