BDBM390021 4-amino-3-(4-phenoxyphenyl)-1- [(3R)-1-[(E)-4-pyrrolidin-1-ylbut-2- enoyl]-3-piperidyl]-6H-pyrrolo[2,3- d]pyridazin-7-one::US10323037, Example 34::US9951077, 34

SMILES: Nc1n[nH]c(=O)c2n(cc(-c3ccc(Oc4ccccc4)cc3)c12)[C@@H]1CCCN(C1)C(=O)\C=C\CN1CCCC1

InChI Key: InChIKey=DTDAAWRYDDIOBP-GULCCPCXSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 390021   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase BTK (Homo sapiens (Human))	BDBM390021 (4-amino-3-(4-phenoxyphenyl)-1- [(3R)-1-[(E)-4-pyrr...) Show SMILES Nc1n[nH]c(=O)c2n(cc(-c3ccc(Oc4ccccc4)cc3)c12)[C@@H]1CCCN(C1)C(=O)\C=C\CN1CCCC1 Show InChI InChI=1S/C31H34N6O3/c32-30-28-26(22-12-14-25(15-13-22)40-24-9-2-1-3-10-24)21-37(29(28)31(39)34-33-30)23-8-6-19-36(20-23)27(38)11-7-18-35-16-4-5-17-35/h1-3,7,9-15,21,23H,4-6,8,16-20H2,(H2,32,33)(H,34,39)/b11-7+/t23-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
JIANGSU HENGRUI MEDICINE CO., LTD. US Patent					Assay Description The Btk kinase assay was performed using a ADP-Glo Btk kinase assay kit purchased from Promega (Madison, Wis.). The assay was conducted according to ...				US Patent US10323037 (2019) BindingDB Entry DOI: 10.7270/Q2W098BW
					More data for this Ligand-Target Pair
Tyrosine-protein kinase BTK (Homo sapiens (Human))	BDBM390021 (4-amino-3-(4-phenoxyphenyl)-1- [(3R)-1-[(E)-4-pyrr...) Show SMILES Nc1n[nH]c(=O)c2n(cc(-c3ccc(Oc4ccccc4)cc3)c12)[C@@H]1CCCN(C1)C(=O)\C=C\CN1CCCC1 Show InChI InChI=1S/C31H34N6O3/c32-30-28-26(22-12-14-25(15-13-22)40-24-9-2-1-3-10-24)21-37(29(28)31(39)34-33-30)23-8-6-19-36(20-23)27(38)11-7-18-35-16-4-5-17-35/h1-3,7,9-15,21,23H,4-6,8,16-20H2,(H2,32,33)(H,34,39)/b11-7+/t23-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The Btk kinase assay was performed using a ADP-Glo Btk kinase assay kit purchased from Promega (Madison, Wis.). The assay was conducted according to ...				Bioorg Med Chem Lett 17: 3972-7 (2007) BindingDB Entry DOI: 10.7270/Q2MG7RV0
					More data for this Ligand-Target Pair