BDBM390034 4-amino-1-[[1-[(E)-4- (dimethylamino)but-2- enoyl]azetidin-3-yl]methyl]-3-(4- phenoxyphenyl)-6H-pyrrolo[2,3- d]pyridazin-7-one::US10323037, Example 47::US9951077, 47

SMILES: CN(C)C\C=C\C(=O)N1CC(Cn2cc(-c3ccc(Oc4ccccc4)cc3)c3c(N)n[nH]c(=O)c23)C1

InChI Key: InChIKey=VYRUICCRBCHNCD-RMKNXTFCSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 390034   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase BTK (Homo sapiens (Human))	BDBM390034 (4-amino-1-[[1-[(E)-4- (dimethylamino)but-2- enoyl]...) Show SMILES CN(C)C\C=C\C(=O)N1CC(Cn2cc(-c3ccc(Oc4ccccc4)cc3)c3c(N)n[nH]c(=O)c23)C1 Show InChI InChI=1S/C28H30N6O3/c1-32(2)14-6-9-24(35)33-15-19(16-33)17-34-18-23(25-26(34)28(36)31-30-27(25)29)20-10-12-22(13-11-20)37-21-7-4-3-5-8-21/h3-13,18-19H,14-17H2,1-2H3,(H2,29,30)(H,31,36)/b9-6+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
JIANGSU HENGRUI MEDICINE CO., LTD. US Patent					Assay Description The Btk kinase assay was performed using a ADP-Glo Btk kinase assay kit purchased from Promega (Madison, Wis.). The assay was conducted according to ...				US Patent US10323037 (2019) BindingDB Entry DOI: 10.7270/Q2W098BW
					More data for this Ligand-Target Pair
Tyrosine-protein kinase BTK (Homo sapiens (Human))	BDBM390034 (4-amino-1-[[1-[(E)-4- (dimethylamino)but-2- enoyl]...) Show SMILES CN(C)C\C=C\C(=O)N1CC(Cn2cc(-c3ccc(Oc4ccccc4)cc3)c3c(N)n[nH]c(=O)c23)C1 Show InChI InChI=1S/C28H30N6O3/c1-32(2)14-6-9-24(35)33-15-19(16-33)17-34-18-23(25-26(34)28(36)31-30-27(25)29)20-10-12-22(13-11-20)37-21-7-4-3-5-8-21/h3-13,18-19H,14-17H2,1-2H3,(H2,29,30)(H,31,36)/b9-6+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The Btk kinase assay was performed using a ADP-Glo Btk kinase assay kit purchased from Promega (Madison, Wis.). The assay was conducted according to ...				Bioorg Med Chem Lett 17: 3972-7 (2007) BindingDB Entry DOI: 10.7270/Q2MG7RV0
					More data for this Ligand-Target Pair