null

SMILES: Nc1n[nH]c(=O)c2n(cc(-c3ccc(Oc4ccccc4F)cc3)c12)[C@@H]1CCCN(C1)C(=O)C=C

InChI Key: InChIKey=KWYUIJZBVYLJQO-QGZVFWFLSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 390043   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase BTK (Homo sapiens (Human))	BDBM390043 (US10323037, Example 56 | US9951077, 56) Show SMILES Nc1n[nH]c(=O)c2n(cc(-c3ccc(Oc4ccccc4F)cc3)c12)[C@@H]1CCCN(C1)C(=O)C=C Show InChI InChI=1S/C26H24FN5O3/c1-2-22(33)31-13-5-6-17(14-31)32-15-19(23-24(32)26(34)30-29-25(23)28)16-9-11-18(12-10-16)35-21-8-4-3-7-20(21)27/h2-4,7-12,15,17H,1,5-6,13-14H2,(H2,28,29)(H,30,34)/t17-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
JIANGSU HENGRUI MEDICINE CO., LTD. US Patent					Assay Description The Btk kinase assay was performed using a ADP-Glo Btk kinase assay kit purchased from Promega (Madison, Wis.). The assay was conducted according to ...				US Patent US10323037 (2019) BindingDB Entry DOI: 10.7270/Q2W098BW
					More data for this Ligand-Target Pair
Tyrosine-protein kinase BTK (Homo sapiens (Human))	BDBM390043 (US10323037, Example 56 | US9951077, 56) Show SMILES Nc1n[nH]c(=O)c2n(cc(-c3ccc(Oc4ccccc4F)cc3)c12)[C@@H]1CCCN(C1)C(=O)C=C Show InChI InChI=1S/C26H24FN5O3/c1-2-22(33)31-13-5-6-17(14-31)32-15-19(23-24(32)26(34)30-29-25(23)28)16-9-11-18(12-10-16)35-21-8-4-3-7-20(21)27/h2-4,7-12,15,17H,1,5-6,13-14H2,(H2,28,29)(H,30,34)/t17-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The Btk kinase assay was performed using a ADP-Glo Btk kinase assay kit purchased from Promega (Madison, Wis.). The assay was conducted according to ...				Bioorg Med Chem Lett 17: 3972-7 (2007) BindingDB Entry DOI: 10.7270/Q2MG7RV0
					More data for this Ligand-Target Pair