BDBM391003 US9957264, Example 5-74::methyl 4-(cyanomethyl)-4- (3-{[2-(cyclopropylmethyl)- 1,1-dioxo-2,3-dihydro-1,2- benzothiazol-5-yl]amino}- 4-oxo-1H,4H,5H-pyrazolo [4,3-c]pyridin-1-yl) piperidine-1-carboxylate
SMILES: COC(=O)N1CCC(CC#N)(CC1)n1nc(Nc2ccc3c(CN(CC4CC4)S3(=O)=O)c2)c2c1cc[nH]c2=O
InChI Key: InChIKey=NPGRFVWWRRRWNJ-UHFFFAOYSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Tyrosine-protein kinase JAK2 (Homo sapiens (Human)) | BDBM391003 (US9957264, Example 5-74 | methyl 4-(cyanomethyl)-4...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.270 | n/a | n/a | n/a | n/a | n/a | n/a |
GSK | Assay Description The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ... | Bioorg Med Chem Lett 19: 360-4 (2009) BindingDB Entry DOI: 10.7270/Q2KH0QN8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase JAK1 (Homo sapiens (Human)) | BDBM391003 (US9957264, Example 5-74 | methyl 4-(cyanomethyl)-4...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.0600 | n/a | n/a | n/a | n/a | n/a | n/a |
GSK | Assay Description The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ... | Bioorg Med Chem Lett 19: 360-4 (2009) BindingDB Entry DOI: 10.7270/Q2KH0QN8 | |||||||||||
More data for this Ligand-Target Pair |