null

SMILES: COc1cc2CN(CCc2cc1Nc1ncc(c(Nc2cccc(NC(=O)C=C)c2)n1)C(F)(F)F)C(C)=O

InChI Key: InChIKey=HXPUBUWIOHZCKU-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 391734   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Epidermal growth factor receptor [T790M] (Homo sapiens (Human))	BDBM391734 (N-(3-((2-((2-acetyl-7-methoxy-1,2,3,4-tetrahydrois...) Show SMILES COc1cc2CN(CCc2cc1Nc1ncc(c(Nc2cccc(NC(=O)C=C)c2)n1)C(F)(F)F)C(C)=O Show InChI InChI=1S/C26H25F3N6O3/c1-4-23(37)31-18-6-5-7-19(12-18)32-24-20(26(27,28)29)13-30-25(34-24)33-21-10-16-8-9-35(15(2)36)14-17(16)11-22(21)38-3/h4-7,10-13H,1,8-9,14H2,2-3H3,(H,31,37)(H2,30,32,33,34)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description Test compounds: a part of compounds of the invention, the chemical names and preparation methods of which can be found in their preparation examples....				Bioorg Med Chem Lett 19: 62-6 (2009) BindingDB Entry DOI: 10.7270/Q2P84F65
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM391734 (N-(3-((2-((2-acetyl-7-methoxy-1,2,3,4-tetrahydrois...) Show SMILES COc1cc2CN(CCc2cc1Nc1ncc(c(Nc2cccc(NC(=O)C=C)c2)n1)C(F)(F)F)C(C)=O Show InChI InChI=1S/C26H25F3N6O3/c1-4-23(37)31-18-6-5-7-19(12-18)32-24-20(26(27,28)29)13-30-25(34-24)33-21-10-16-8-9-35(15(2)36)14-17(16)11-22(21)38-3/h4-7,10-13H,1,8-9,14H2,2-3H3,(H,31,37)(H2,30,32,33,34)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	640	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description Test compounds: a part of compounds of the invention, the chemical names and preparation methods of which can be found in their preparation examples....				Bioorg Med Chem Lett 19: 62-6 (2009) BindingDB Entry DOI: 10.7270/Q2P84F65
					More data for this Ligand-Target Pair