BDBM391742 N-(3-((2-((2-methoxy-4-(1-(methylsulfonyl)piperidin-4-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)phenyl)acrylamide ::US10300058, Compound 27

SMILES: COc1cc(ccc1Nc1ncc(c(Nc2cccc(NC(=O)C=C)c2)n1)C(F)(F)F)C1CCN(CC1)S(C)(=O)=O

InChI Key: InChIKey=WQGDMILUIXEUMW-UHFFFAOYSA-N

Data: 6 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 391742   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM391742 (N-(3-((2-((2-methoxy-4-(1-(methylsulfonyl)piperidi...) Show SMILES COc1cc(ccc1Nc1ncc(c(Nc2cccc(NC(=O)C=C)c2)n1)C(F)(F)F)C1CCN(CC1)S(C)(=O)=O Show InChI InChI=1S/C27H29F3N6O4S/c1-4-24(37)32-19-6-5-7-20(15-19)33-25-21(27(28,29)30)16-31-26(35-25)34-22-9-8-18(14-23(22)40-2)17-10-12-36(13-11-17)41(3,38)39/h4-9,14-17H,1,10-13H2,2-3H3,(H,32,37)(H2,31,33,34,35)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	8.71E+5	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description Test compounds: a part of compounds of the invention, the chemical names and preparation methods of which can be found in their preparation examples....				Bioorg Med Chem Lett 19: 62-6 (2009) BindingDB Entry DOI: 10.7270/Q2P84F65
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (T790M) (Homo sapiens (Human))	BDBM391742 (N-(3-((2-((2-methoxy-4-(1-(methylsulfonyl)piperidi...) Show SMILES COc1cc(ccc1Nc1ncc(c(Nc2cccc(NC(=O)C=C)c2)n1)C(F)(F)F)C1CCN(CC1)S(C)(=O)=O Show InChI InChI=1S/C27H29F3N6O4S/c1-4-24(37)32-19-6-5-7-20(15-19)33-25-21(27(28,29)30)16-31-26(35-25)34-22-9-8-18(14-23(22)40-2)17-10-12-36(13-11-17)41(3,38)39/h4-9,14-17H,1,10-13H2,2-3H3,(H,32,37)(H2,31,33,34,35)	PDB MMDB B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	9.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description Test compounds: a part of compounds of the invention, the chemical names and preparation methods of which can be found in their preparation examples....				Bioorg Med Chem Lett 19: 62-6 (2009) BindingDB Entry DOI: 10.7270/Q2P84F65
					More data for this Ligand-Target Pair
EGFR (d746-750)-T790M (Homo sapiens (Human))	BDBM391742 (N-(3-((2-((2-methoxy-4-(1-(methylsulfonyl)piperidi...) Show SMILES COc1cc(ccc1Nc1ncc(c(Nc2cccc(NC(=O)C=C)c2)n1)C(F)(F)F)C1CCN(CC1)S(C)(=O)=O Show InChI InChI=1S/C27H29F3N6O4S/c1-4-24(37)32-19-6-5-7-20(15-19)33-25-21(27(28,29)30)16-31-26(35-25)34-22-9-8-18(14-23(22)40-2)17-10-12-36(13-11-17)41(3,38)39/h4-9,14-17H,1,10-13H2,2-3H3,(H,32,37)(H2,31,33,34,35)	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.60	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description Test compounds: a part of compounds of the invention, the chemical names and preparation methods of which can be found in their preparation examples....				Bioorg Med Chem Lett 19: 62-6 (2009) BindingDB Entry DOI: 10.7270/Q2P84F65
					More data for this Ligand-Target Pair
Epidermal growth factor receptor(L858R, T790M) (Homo sapiens (Human))	BDBM391742 (N-(3-((2-((2-methoxy-4-(1-(methylsulfonyl)piperidi...) Show SMILES COc1cc(ccc1Nc1ncc(c(Nc2cccc(NC(=O)C=C)c2)n1)C(F)(F)F)C1CCN(CC1)S(C)(=O)=O Show InChI InChI=1S/C27H29F3N6O4S/c1-4-24(37)32-19-6-5-7-20(15-19)33-25-21(27(28,29)30)16-31-26(35-25)34-22-9-8-18(14-23(22)40-2)17-10-12-36(13-11-17)41(3,38)39/h4-9,14-17H,1,10-13H2,2-3H3,(H,32,37)(H2,31,33,34,35)	PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	9.80	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description Test compounds: a part of compounds of the invention, the chemical names and preparation methods of which can be found in their preparation examples....				Bioorg Med Chem Lett 19: 62-6 (2009) BindingDB Entry DOI: 10.7270/Q2P84F65
					More data for this Ligand-Target Pair
EGFR (del 746-750) (Homo sapiens (Human))	BDBM391742 (N-(3-((2-((2-methoxy-4-(1-(methylsulfonyl)piperidi...) Show SMILES COc1cc(ccc1Nc1ncc(c(Nc2cccc(NC(=O)C=C)c2)n1)C(F)(F)F)C1CCN(CC1)S(C)(=O)=O Show InChI InChI=1S/C27H29F3N6O4S/c1-4-24(37)32-19-6-5-7-20(15-19)33-25-21(27(28,29)30)16-31-26(35-25)34-22-9-8-18(14-23(22)40-2)17-10-12-36(13-11-17)41(3,38)39/h4-9,14-17H,1,10-13H2,2-3H3,(H,32,37)(H2,31,33,34,35)	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	36	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description Test compounds: a part of compounds of the invention, the chemical names and preparation methods of which can be found in their preparation examples....				Bioorg Med Chem Lett 19: 62-6 (2009) BindingDB Entry DOI: 10.7270/Q2P84F65
					More data for this Ligand-Target Pair
EGFR(L858R) (Homo sapiens (Human))	BDBM391742 (N-(3-((2-((2-methoxy-4-(1-(methylsulfonyl)piperidi...) Show SMILES COc1cc(ccc1Nc1ncc(c(Nc2cccc(NC(=O)C=C)c2)n1)C(F)(F)F)C1CCN(CC1)S(C)(=O)=O Show InChI InChI=1S/C27H29F3N6O4S/c1-4-24(37)32-19-6-5-7-20(15-19)33-25-21(27(28,29)30)16-31-26(35-25)34-22-9-8-18(14-23(22)40-2)17-10-12-36(13-11-17)41(3,38)39/h4-9,14-17H,1,10-13H2,2-3H3,(H,32,37)(H2,31,33,34,35)	PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	88	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description Test compounds: a part of compounds of the invention, the chemical names and preparation methods of which can be found in their preparation examples....				Bioorg Med Chem Lett 19: 62-6 (2009) BindingDB Entry DOI: 10.7270/Q2P84F65
					More data for this Ligand-Target Pair