BDBM391743 N-(3-((2-((2-methoxy-4-(4-morpholinopiperidin-1-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)phenyl)acrylamide ::US10300058, Compound 28
SMILES: COc1cc(ccc1Nc1ncc(c(Nc2cccc(NC(=O)C=C)c2)n1)C(F)(F)F)N1CCC(CC1)N1CCOCC1
InChI Key: InChIKey=XZALXIFAYPBZQA-UHFFFAOYSA-N
Data: 6 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Epidermal growth factor receptor (Homo sapiens (Human)) | BDBM391743 (N-(3-((2-((2-methoxy-4-(4-morpholinopiperidin-1-yl...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 7.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research | Assay Description Test compounds: a part of compounds of the invention, the chemical names and preparation methods of which can be found in their preparation examples.... | Bioorg Med Chem Lett 19: 62-6 (2009) BindingDB Entry DOI: 10.7270/Q2P84F65 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor (T790M) (Homo sapiens (Human)) | BDBM391743 (N-(3-((2-((2-methoxy-4-(4-morpholinopiperidin-1-yl...) | PDB MMDB B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research | Assay Description Test compounds: a part of compounds of the invention, the chemical names and preparation methods of which can be found in their preparation examples.... | Bioorg Med Chem Lett 19: 62-6 (2009) BindingDB Entry DOI: 10.7270/Q2P84F65 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
EGFR (d746-750)-T790M (Homo sapiens (Human)) | BDBM391743 (N-(3-((2-((2-methoxy-4-(4-morpholinopiperidin-1-yl...) | PDB GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.800 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research | Assay Description Test compounds: a part of compounds of the invention, the chemical names and preparation methods of which can be found in their preparation examples.... | Bioorg Med Chem Lett 19: 62-6 (2009) BindingDB Entry DOI: 10.7270/Q2P84F65 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor(L858R, T790M) (Homo sapiens (Human)) | BDBM391743 (N-(3-((2-((2-methoxy-4-(4-morpholinopiperidin-1-yl...) | PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research | Assay Description Test compounds: a part of compounds of the invention, the chemical names and preparation methods of which can be found in their preparation examples.... | Bioorg Med Chem Lett 19: 62-6 (2009) BindingDB Entry DOI: 10.7270/Q2P84F65 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
EGFR (del 746-750) (Homo sapiens (Human)) | BDBM391743 (N-(3-((2-((2-methoxy-4-(4-morpholinopiperidin-1-yl...) | PDB GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 5.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research | Assay Description Test compounds: a part of compounds of the invention, the chemical names and preparation methods of which can be found in their preparation examples.... | Bioorg Med Chem Lett 19: 62-6 (2009) BindingDB Entry DOI: 10.7270/Q2P84F65 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
EGFR(L858R) (Homo sapiens (Human)) | BDBM391743 (N-(3-((2-((2-methoxy-4-(4-morpholinopiperidin-1-yl...) | PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research | Assay Description Test compounds: a part of compounds of the invention, the chemical names and preparation methods of which can be found in their preparation examples.... | Bioorg Med Chem Lett 19: 62-6 (2009) BindingDB Entry DOI: 10.7270/Q2P84F65 | |||||||||||
More data for this Ligand-Target Pair |