BDBM391827 US10300074, Compd 22::US10300074, Compd 23
SMILES: CN[C@@H](C)C(=O)N[C@H]1CCO[C@H]2CCC(N2C1=O)C(=O)n1ccc2ccccc12
InChI Key: InChIKey=MVTULAMVOISCBR-FDGRXGLPSA-N
Data: 4 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
BIR3 (aa 241-356) (Homo sapiens (Human)) | BDBM391827 (US10300074, Compd 22 | US10300074, Compd 23) | PDB GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 3.75E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GSK | Assay Description 5000 PPC-1 cells were plated and grown overnight. Compounds were plated and 4 hrs later, TRAIL was added to half of the plate while RPMI was added to... | Bioorg Med Chem Lett 19: 1807-10 (2009) BindingDB Entry DOI: 10.7270/Q25B04VG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
BIR3 (aa 241-356) (Homo sapiens (Human)) | BDBM391827 (US10300074, Compd 22 | US10300074, Compd 23) | PDB GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 3.75E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GSK | Assay Description 5000 PPC-1 cells were plated and grown overnight. Compounds were plated and 4 hrs later, TRAIL was added to half of the plate while RPMI was added to... | Bioorg Med Chem Lett 19: 1807-10 (2009) BindingDB Entry DOI: 10.7270/Q25B04VG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
XIAP BIR1/2 (Homo sapiens (Human)) | BDBM391827 (US10300074, Compd 22 | US10300074, Compd 23) | PDB MMDB NCI pathway Reactome pathway KEGG B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GSK | Assay Description 5000 PPC-1 cells were plated and grown overnight. Compounds were plated and 4 hrs later, TRAIL was added to half of the plate while RPMI was added to... | Bioorg Med Chem Lett 19: 1807-10 (2009) BindingDB Entry DOI: 10.7270/Q25B04VG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
XIAP BIR1/2 (Homo sapiens (Human)) | BDBM391827 (US10300074, Compd 22 | US10300074, Compd 23) | PDB MMDB NCI pathway Reactome pathway KEGG B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GSK | Assay Description 5000 PPC-1 cells were plated and grown overnight. Compounds were plated and 4 hrs later, TRAIL was added to half of the plate while RPMI was added to... | Bioorg Med Chem Lett 19: 1807-10 (2009) BindingDB Entry DOI: 10.7270/Q25B04VG | |||||||||||
More data for this Ligand-Target Pair |