Found 3 hits for monomerid = 392043 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Isoform 2 of Nuclear receptor ROR-gamma (RORgT)
(Homo sapiens (Human)) | BDBM392043
(US10301272, Example 6/41)Show SMILES CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(nc2CC2CCCCC2)C(=O)N[C@H]2C[C@@H](C2)S(C)(=O)=O)c(Cl)c1Cl |r,wU:27.28,wD:29.33,(8.18,-4.16,;7.41,-2.83,;5.87,-2.83,;6.64,-4.16,;8.18,-1.49,;7.41,-.16,;7.41,1.38,;8.75,.61,;5.87,-.16,;5.1,-1.49,;3.56,-1.49,;2.79,-.16,;1.25,-.16,;.35,1.09,;-1.12,.61,;-1.12,-.93,;.35,-1.41,;.75,-2.89,;-.34,-3.98,;-1.83,-3.58,;-2.92,-4.67,;-2.52,-6.16,;-1.03,-6.56,;.06,-5.47,;-2.21,1.7,;-1.81,3.19,;-3.69,1.3,;-4.78,2.39,;-6.32,2.39,;-6.32,3.93,;-4.78,3.93,;-7.41,5.02,;-7.41,6.56,;-8.75,4.25,;-7.41,3.48,;3.56,1.17,;2.79,2.51,;5.1,1.17,;5.87,2.51,)| Show InChI InChI=1S/C26H35Cl2N3O5S3/c1-26(2,3)31-39(35,36)20-11-10-18(21(27)22(20)28)23-19(12-15-8-6-5-7-9-15)30-25(37-23)24(32)29-16-13-17(14-16)38(4,33)34/h10-11,15-17,31H,5-9,12-14H2,1-4H3,(H,29,32)/t16-,17- | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 50.1 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharmaceuticals Inc.
| Assay Description
Determination of a ligand mediated Gal4 promoter driven transactivation to quantify ligand binding to RORγ was performed as follows: DNA encodin... |
J Med Chem 52: 1814-27 (2009)
BindingDB Entry DOI: 10.7270/Q2S184TJ |
More data for this
Ligand-Target Pair | |
Isoform 2 of Nuclear receptor ROR-gamma (RORgT)
(Homo sapiens (Human)) | BDBM392043
(US10301272, Example 6/41)Show SMILES CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(nc2CC2CCCCC2)C(=O)N[C@H]2C[C@@H](C2)S(C)(=O)=O)c(Cl)c1Cl |r,wU:27.28,wD:29.33,(8.18,-4.16,;7.41,-2.83,;5.87,-2.83,;6.64,-4.16,;8.18,-1.49,;7.41,-.16,;7.41,1.38,;8.75,.61,;5.87,-.16,;5.1,-1.49,;3.56,-1.49,;2.79,-.16,;1.25,-.16,;.35,1.09,;-1.12,.61,;-1.12,-.93,;.35,-1.41,;.75,-2.89,;-.34,-3.98,;-1.83,-3.58,;-2.92,-4.67,;-2.52,-6.16,;-1.03,-6.56,;.06,-5.47,;-2.21,1.7,;-1.81,3.19,;-3.69,1.3,;-4.78,2.39,;-6.32,2.39,;-6.32,3.93,;-4.78,3.93,;-7.41,5.02,;-7.41,6.56,;-8.75,4.25,;-7.41,3.48,;3.56,1.17,;2.79,2.51,;5.1,1.17,;5.87,2.51,)| Show InChI InChI=1S/C26H35Cl2N3O5S3/c1-26(2,3)31-39(35,36)20-11-10-18(21(27)22(20)28)23-19(12-15-8-6-5-7-9-15)30-25(37-23)24(32)29-16-13-17(14-16)38(4,33)34/h10-11,15-17,31H,5-9,12-14H2,1-4H3,(H,29,32)/t16-,17- | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 6.31 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharmaceuticals Inc.
| Assay Description
Cells were incubated for additional 16 h before renilla (REN) luciferase activities were measured sequentially in the same cell extract using a Dual-... |
J Med Chem 52: 1814-27 (2009)
BindingDB Entry DOI: 10.7270/Q2S184TJ |
More data for this
Ligand-Target Pair | |
Isoform 2 of Nuclear receptor ROR-gamma (RORgT)
(Homo sapiens (Human)) | BDBM392043
(US10301272, Example 6/41)Show SMILES CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(nc2CC2CCCCC2)C(=O)N[C@H]2C[C@@H](C2)S(C)(=O)=O)c(Cl)c1Cl |r,wU:27.28,wD:29.33,(8.18,-4.16,;7.41,-2.83,;5.87,-2.83,;6.64,-4.16,;8.18,-1.49,;7.41,-.16,;7.41,1.38,;8.75,.61,;5.87,-.16,;5.1,-1.49,;3.56,-1.49,;2.79,-.16,;1.25,-.16,;.35,1.09,;-1.12,.61,;-1.12,-.93,;.35,-1.41,;.75,-2.89,;-.34,-3.98,;-1.83,-3.58,;-2.92,-4.67,;-2.52,-6.16,;-1.03,-6.56,;.06,-5.47,;-2.21,1.7,;-1.81,3.19,;-3.69,1.3,;-4.78,2.39,;-6.32,2.39,;-6.32,3.93,;-4.78,3.93,;-7.41,5.02,;-7.41,6.56,;-8.75,4.25,;-7.41,3.48,;3.56,1.17,;2.79,2.51,;5.1,1.17,;5.87,2.51,)| Show InChI InChI=1S/C26H35Cl2N3O5S3/c1-26(2,3)31-39(35,36)20-11-10-18(21(27)22(20)28)23-19(12-15-8-6-5-7-9-15)30-25(37-23)24(32)29-16-13-17(14-16)38(4,33)34/h10-11,15-17,31H,5-9,12-14H2,1-4H3,(H,29,32)/t16-,17- | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharmaceuticals Inc.
| Assay Description
Cells were incubated for additional 16 h before firefly (FF) luciferase activities were measured sequentially in the same cell extract using a Dual-L... |
J Med Chem 52: 1814-27 (2009)
BindingDB Entry DOI: 10.7270/Q2S184TJ |
More data for this
Ligand-Target Pair | |
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