Found 3 hits for monomerid = 392044 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Isoform 2 of Nuclear receptor ROR-gamma (RORgT)
(Homo sapiens (Human)) | BDBM392044
(US10301272, Example 6/42)Show SMILES CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(nc2CC2CCCCC2)C(=O)N[C@H]2C[C@H](C2)S(C)(=O)=O)c(Cl)c1Cl |r,wU:27.28,29.33,(8.29,-4.16,;7.52,-2.83,;5.98,-2.83,;6.75,-4.16,;8.29,-1.49,;7.52,-.16,;7.52,1.38,;8.85,.61,;5.98,-.16,;5.21,-1.49,;3.67,-1.49,;2.9,-.16,;1.36,-.16,;.45,1.09,;-1.01,.61,;-1.01,-.93,;.45,-1.41,;.85,-2.89,;-.24,-3.98,;-1.73,-3.58,;-2.82,-4.67,;-2.42,-6.16,;-.93,-6.56,;.16,-5.47,;-2.1,1.7,;-1.71,3.19,;-3.59,1.3,;-4.68,2.39,;-6.22,2.39,;-6.22,3.93,;-4.68,3.93,;-7.31,5.02,;-7.31,6.56,;-8.85,5.02,;-8.08,3.68,;3.67,1.17,;2.9,2.51,;5.21,1.17,;5.98,2.51,)| Show InChI InChI=1S/C26H35Cl2N3O5S3/c1-26(2,3)31-39(35,36)20-11-10-18(21(27)22(20)28)23-19(12-15-8-6-5-7-9-15)30-25(37-23)24(32)29-16-13-17(14-16)38(4,33)34/h10-11,15-17,31H,5-9,12-14H2,1-4H3,(H,29,32)/t16-,17+ | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 63.1 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharmaceuticals Inc.
| Assay Description
Determination of a ligand mediated Gal4 promoter driven transactivation to quantify ligand binding to RORγ was performed as follows: DNA encodin... |
J Med Chem 52: 1814-27 (2009)
BindingDB Entry DOI: 10.7270/Q2S184TJ |
More data for this
Ligand-Target Pair | |
Isoform 2 of Nuclear receptor ROR-gamma (RORgT)
(Homo sapiens (Human)) | BDBM392044
(US10301272, Example 6/42)Show SMILES CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(nc2CC2CCCCC2)C(=O)N[C@H]2C[C@H](C2)S(C)(=O)=O)c(Cl)c1Cl |r,wU:27.28,29.33,(8.29,-4.16,;7.52,-2.83,;5.98,-2.83,;6.75,-4.16,;8.29,-1.49,;7.52,-.16,;7.52,1.38,;8.85,.61,;5.98,-.16,;5.21,-1.49,;3.67,-1.49,;2.9,-.16,;1.36,-.16,;.45,1.09,;-1.01,.61,;-1.01,-.93,;.45,-1.41,;.85,-2.89,;-.24,-3.98,;-1.73,-3.58,;-2.82,-4.67,;-2.42,-6.16,;-.93,-6.56,;.16,-5.47,;-2.1,1.7,;-1.71,3.19,;-3.59,1.3,;-4.68,2.39,;-6.22,2.39,;-6.22,3.93,;-4.68,3.93,;-7.31,5.02,;-7.31,6.56,;-8.85,5.02,;-8.08,3.68,;3.67,1.17,;2.9,2.51,;5.21,1.17,;5.98,2.51,)| Show InChI InChI=1S/C26H35Cl2N3O5S3/c1-26(2,3)31-39(35,36)20-11-10-18(21(27)22(20)28)23-19(12-15-8-6-5-7-9-15)30-25(37-23)24(32)29-16-13-17(14-16)38(4,33)34/h10-11,15-17,31H,5-9,12-14H2,1-4H3,(H,29,32)/t16-,17+ | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 3.98 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharmaceuticals Inc.
| Assay Description
Cells were incubated for additional 16 h before renilla (REN) luciferase activities were measured sequentially in the same cell extract using a Dual-... |
J Med Chem 52: 1814-27 (2009)
BindingDB Entry DOI: 10.7270/Q2S184TJ |
More data for this
Ligand-Target Pair | |
Isoform 2 of Nuclear receptor ROR-gamma (RORgT)
(Homo sapiens (Human)) | BDBM392044
(US10301272, Example 6/42)Show SMILES CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(nc2CC2CCCCC2)C(=O)N[C@H]2C[C@H](C2)S(C)(=O)=O)c(Cl)c1Cl |r,wU:27.28,29.33,(8.29,-4.16,;7.52,-2.83,;5.98,-2.83,;6.75,-4.16,;8.29,-1.49,;7.52,-.16,;7.52,1.38,;8.85,.61,;5.98,-.16,;5.21,-1.49,;3.67,-1.49,;2.9,-.16,;1.36,-.16,;.45,1.09,;-1.01,.61,;-1.01,-.93,;.45,-1.41,;.85,-2.89,;-.24,-3.98,;-1.73,-3.58,;-2.82,-4.67,;-2.42,-6.16,;-.93,-6.56,;.16,-5.47,;-2.1,1.7,;-1.71,3.19,;-3.59,1.3,;-4.68,2.39,;-6.22,2.39,;-6.22,3.93,;-4.68,3.93,;-7.31,5.02,;-7.31,6.56,;-8.85,5.02,;-8.08,3.68,;3.67,1.17,;2.9,2.51,;5.21,1.17,;5.98,2.51,)| Show InChI InChI=1S/C26H35Cl2N3O5S3/c1-26(2,3)31-39(35,36)20-11-10-18(21(27)22(20)28)23-19(12-15-8-6-5-7-9-15)30-25(37-23)24(32)29-16-13-17(14-16)38(4,33)34/h10-11,15-17,31H,5-9,12-14H2,1-4H3,(H,29,32)/t16-,17+ | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 6.31 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharmaceuticals Inc.
| Assay Description
Cells were incubated for additional 16 h before firefly (FF) luciferase activities were measured sequentially in the same cell extract using a Dual-L... |
J Med Chem 52: 1814-27 (2009)
BindingDB Entry DOI: 10.7270/Q2S184TJ |
More data for this
Ligand-Target Pair | |
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