null

SMILES: CC(C)(C)c1cc(cc(c1)C1(C)CC1)-c1sc(nc1CC1CCCCC1)C(=O)NC1CCOCC1

InChI Key: InChIKey=FUZUEQZMCGGQEN-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 392095   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Isoform 2 of Nuclear receptor ROR-gamma (RORgT) (Homo sapiens (Human))	BDBM392095 (US10301272, Example 8) Show SMILES CC(C)(C)c1cc(cc(c1)C1(C)CC1)-c1sc(nc1CC1CCCCC1)C(=O)NC1CCOCC1 Show InChI InChI=1S/C30H42N2O2S/c1-29(2,3)22-17-21(18-23(19-22)30(4)12-13-30)26-25(16-20-8-6-5-7-9-20)32-28(35-26)27(33)31-24-10-14-34-15-11-24/h17-20,24H,5-16H2,1-4H3,(H,31,33)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim Pharmaceuticals Inc.					Assay Description Determination of a ligand mediated Gal4 promoter driven transactivation to quantify ligand binding to RORγ was performed as follows: DNA encodin...				J Med Chem 52: 1814-27 (2009) BindingDB Entry DOI: 10.7270/Q2S184TJ
					More data for this Ligand-Target Pair
Isoform 2 of Nuclear receptor ROR-gamma (RORgT) (Homo sapiens (Human))	BDBM392095 (US10301272, Example 8) Show SMILES CC(C)(C)c1cc(cc(c1)C1(C)CC1)-c1sc(nc1CC1CCCCC1)C(=O)NC1CCOCC1 Show InChI InChI=1S/C30H42N2O2S/c1-29(2,3)22-17-21(18-23(19-22)30(4)12-13-30)26-25(16-20-8-6-5-7-9-20)32-28(35-26)27(33)31-24-10-14-34-15-11-24/h17-20,24H,5-16H2,1-4H3,(H,31,33)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	31.6	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim Pharmaceuticals Inc.					Assay Description Cells were incubated for additional 16 h before renilla (REN) luciferase activities were measured sequentially in the same cell extract using a Dual-...				J Med Chem 52: 1814-27 (2009) BindingDB Entry DOI: 10.7270/Q2S184TJ
					More data for this Ligand-Target Pair
Isoform 2 of Nuclear receptor ROR-gamma (RORgT) (Homo sapiens (Human))	BDBM392095 (US10301272, Example 8) Show SMILES CC(C)(C)c1cc(cc(c1)C1(C)CC1)-c1sc(nc1CC1CCCCC1)C(=O)NC1CCOCC1 Show InChI InChI=1S/C30H42N2O2S/c1-29(2,3)22-17-21(18-23(19-22)30(4)12-13-30)26-25(16-20-8-6-5-7-9-20)32-28(35-26)27(33)31-24-10-14-34-15-11-24/h17-20,24H,5-16H2,1-4H3,(H,31,33)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	50.1	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim Pharmaceuticals Inc.					Assay Description Cells were incubated for additional 16 h before firefly (FF) luciferase activities were measured sequentially in the same cell extract using a Dual-L...				J Med Chem 52: 1814-27 (2009) BindingDB Entry DOI: 10.7270/Q2S184TJ
					More data for this Ligand-Target Pair