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SMILES: N#CCc1cnc(-c2ccc3OCOc3c2)n1-c1ccnc(NC2CCCCC2)n1

InChI Key: InChIKey=OFUMROLKEGKJMS-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 392713   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Mitogen-activated protein kinase 10


(Homo sapiens (Human))		BDBM392713
PNG
(Example 7 | US10301291, Compound 11a)
Show SMILES N#CCc1cnc(-c2ccc3OCOc3c2)n1-c1ccnc(NC2CCCCC2)n1
Show InChI InChI=1S/C22H22N6O2/c23-10-8-17-13-25-21(15-6-7-18-19(12-15)30-14-29-18)28(17)20-9-11-24-22(27-20)26-16-4-2-1-3-5-16/h6-7,9,11-13,16H,1-5,8,14H2,(H,24,26,27)
PDB
MMDB

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US Patent
n/an/a>100n/an/an/an/an/an/a



Bristol-Myers Squibb Company



Assay Description
First of all, after a substrate was inserted into a prepared base reaction buffer solution (20 mM Hepes (pH 75), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35...

J Med Chem 52: 1994-2005 (2009)


BindingDB Entry DOI: 10.7270/Q20K2BW1
More data for this
Ligand-Target Pair