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SMILES: N#CCc1cnc(-c2ccc3ccccc3n2)n1-c1ccnc(NC2CCCNC2)n1

InChI Key: InChIKey=MANNUZLBILGUDA-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 392727   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Mitogen-activated protein kinase 10


(Homo sapiens (Human))		BDBM392727
PNG
(Example 27 | US10301291, Compound 14c)
Show SMILES N#CCc1cnc(-c2ccc3ccccc3n2)n1-c1ccnc(NC2CCCNC2)n1
Show InChI InChI=1S/C23H22N8/c24-11-9-18-15-27-22(20-8-7-16-4-1-2-6-19(16)29-20)31(18)21-10-13-26-23(30-21)28-17-5-3-12-25-14-17/h1-2,4,6-8,10,13,15,17,25H,3,5,9,12,14H2,(H,26,28,30)
PDB
MMDB

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US Patent
n/an/a 65n/an/an/an/an/an/a



Bristol-Myers Squibb Company



Assay Description
First of all, after a substrate was inserted into a prepared base reaction buffer solution (20 mM Hepes (pH 75), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35...

J Med Chem 52: 1994-2005 (2009)


BindingDB Entry DOI: 10.7270/Q20K2BW1
More data for this
Ligand-Target Pair