BDBM392763 1′-Cyclohexyl-6-(4-methyl-piperazin-1-yl)-1H,1′H-[4,5′]bibenzimidazolyl-7-carboxamide::US10301305, Example 106

SMILES: CN1CCN(CC1)c1cc(-c2ccc3n(cnc3c2)C2CCCCC2)c2nc[nH]c2c1C(N)=O

InChI Key: InChIKey=MNTLIEPXNVSQJN-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 392763   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
D-alanine--D-alanyl carrier protein ligase (Staphylococcus aureus (strain SA113))	BDBM392763 (1′-Cyclohexyl-6-(4-methyl-piperazin-1-yl)-1H...) Show SMILES CN1CCN(CC1)c1cc(-c2ccc3n(cnc3c2)C2CCCCC2)c2nc[nH]c2c1C(N)=O Show InChI InChI=1S/C26H31N7O/c1-31-9-11-32(12-10-31)22-14-19(24-25(29-15-28-24)23(22)26(27)34)17-7-8-21-20(13-17)30-16-33(21)18-5-3-2-4-6-18/h7-8,13-16,18H,2-6,9-12H2,1H3,(H2,27,34)(H,28,29)	MMDB NCI pathway Reactome pathway KEGG UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	34	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The assay buffer “AB” contained 50 mM Hepes pH8.0, 10 mM MgCl2, 50 mM KCl, 0.012% Triton-X100, 10 mM DTT and 100 nM Myelin-basic protein. The followi...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2R213Q5
					More data for this Ligand-Target Pair
D-alanine--D-alanyl carrier protein ligase (Streptococcus agalactiae serotype V (strain ATCC B...)	BDBM392763 (1′-Cyclohexyl-6-(4-methyl-piperazin-1-yl)-1H...) Show SMILES CN1CCN(CC1)c1cc(-c2ccc3n(cnc3c2)C2CCCCC2)c2nc[nH]c2c1C(N)=O Show InChI InChI=1S/C26H31N7O/c1-31-9-11-32(12-10-31)22-14-19(24-25(29-15-28-24)23(22)26(27)34)17-7-8-21-20(13-17)30-16-33(21)18-5-3-2-4-6-18/h7-8,13-16,18H,2-6,9-12H2,1H3,(H2,27,34)(H,28,29)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	500	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The assay buffer “AB” contained 50 mM Hepes pH8.0, 10 mM MgCl2, 50 mM KCl, 0.012% Triton-X100, 10 mM DTT and 100 nM Myelin-basic protein. The followi...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2R213Q5
					More data for this Ligand-Target Pair
D-alanine--D-alanyl carrier protein ligase (Enterococcus faecium E1679)	BDBM392763 (1′-Cyclohexyl-6-(4-methyl-piperazin-1-yl)-1H...) Show SMILES CN1CCN(CC1)c1cc(-c2ccc3n(cnc3c2)C2CCCCC2)c2nc[nH]c2c1C(N)=O Show InChI InChI=1S/C26H31N7O/c1-31-9-11-32(12-10-31)22-14-19(24-25(29-15-28-24)23(22)26(27)34)17-7-8-21-20(13-17)30-16-33(21)18-5-3-2-4-6-18/h7-8,13-16,18H,2-6,9-12H2,1H3,(H2,27,34)(H,28,29)	MMDB NCI pathway Reactome pathway KEGG UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	76	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The assay buffer “AB” contained 50 mM Hepes pH8.0, 10 mM MgCl2, 50 mM KCl, 0.012% Triton-X100, 10 mM DTT and 100 nM Myelin-basic protein. The followi...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2R213Q5
					More data for this Ligand-Target Pair
D-alanine--D-alanyl carrier protein ligase (Enterococcus faecalis (strain ATCC 700802 / V583))	BDBM392763 (1′-Cyclohexyl-6-(4-methyl-piperazin-1-yl)-1H...) Show SMILES CN1CCN(CC1)c1cc(-c2ccc3n(cnc3c2)C2CCCCC2)c2nc[nH]c2c1C(N)=O Show InChI InChI=1S/C26H31N7O/c1-31-9-11-32(12-10-31)22-14-19(24-25(29-15-28-24)23(22)26(27)34)17-7-8-21-20(13-17)30-16-33(21)18-5-3-2-4-6-18/h7-8,13-16,18H,2-6,9-12H2,1H3,(H2,27,34)(H,28,29)	MMDB KEGG UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	18	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The assay buffer “AB” contained 50 mM Hepes pH8.0, 10 mM MgCl2, 50 mM KCl, 0.012% Triton-X100, 10 mM DTT and 100 nM Myelin-basic protein. The followi...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2R213Q5
					More data for this Ligand-Target Pair