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SMILES: Cc1noc(n1)-c1ccc(Cn2c3CCNC(=O)c3c(c2-c2ccncc2)-c2ccc(F)cc2)cc1

InChI Key: InChIKey=MHXMNRFUINZABZ-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 392815   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Receptor-interacting serine/threonine-protein kinase 3


(Homo sapiens (Human))		BDBM392815
PNG
(3-(4-Fluorophenyl)-1-(4-(3-methyl-1,2,4-oxadiazol-...)
Show SMILES Cc1noc(n1)-c1ccc(Cn2c3CCNC(=O)c3c(c2-c2ccncc2)-c2ccc(F)cc2)cc1
Show InChI InChI=1S/C28H22FN5O2/c1-17-32-28(36-33-17)21-4-2-18(3-5-21)16-34-23-12-15-31-27(35)25(23)24(19-6-8-22(29)9-7-19)26(34)20-10-13-30-14-11-20/h2-11,13-14H,12,15-16H2,1H3,(H,31,35)
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n/an/a<30n/an/an/an/an/an/a



GSK



Assay Description
The assays were performed in black 1536-well plates. The final assay volume of 2 μl contained a mixture of a fluorescently labeled HTRF probe, T...

Bioorg Med Chem Lett 18: 5018-22 (2008)


BindingDB Entry DOI: 10.7270/Q2M90C19
More data for this
Ligand-Target Pair